期刊论文

Hou, Yongqing

英文

Amino Acids

0939-4451

2012

43

3

1233-1242

10.1007/s00726-011-1191-9

This research was jointly supported by the National Natural Science Foundation of China (Grant No. 30871801), National Natural Science Foundation of China (No. 30972213), Wuhan Disciplines Leaders Project (Grant No. 200951830554), the Program for Innovative Research Groups of Hubei Provincial Natural Science Foundation (Grant No. 2007ABC009) and National Research Initiative Competitive Grants from the Animal Growth and Nutrient Utilization Program (2008-35206-18764) of the USDA National Institute of Food and Agriculture and Texas AgriLife Research (H-82000).

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The neonatal small intestine is susceptible to damage by endotoxin, but effective methods for prevention and treatment are lacking. N-acetylcysteine (NAC) is a widely used precursor of L-cysteine for animal cells and plays an important role in protecting cells against oxidative stress. This study was conducted with the lipopolysaccharide (LPS)-challenged piglet model to determine the effects of NAC on intestinal function. Eighteen piglets were randomly allocated into control, LPS and LPS + NAC groups. The control and LPS groups were fed a corn-...