通讯机构:
[Chen, H.] L;Laboratory of Genetic Breeding Reproduction and Precision Livestock Farming, Hubei, China
关键词:
Introduction;Materials and Methods;Results;Discussion;Conclusion;Abstract;Data Availability;Additional Points;Ethical Approval;Consent;Disclosure;Conflicts of Interests;Authors’ Contributions;Funding Statement;Acknowledgements;Acknowledgments;Supplementary Materials;Reference;Dataset Description;Dataset Files;Abstract;Introduction;Introduction and Materials;Introduction and Methods;Materials;Materials and Methods;Methods;Results;Discussion;Results and Discussion;Discussion and Conclusion;Results and Conclusion;Conclusion;Conclusions;Data Availability;Additional Points;Ethical Approval;Consent;Disclosure;Conflicts of Interest;Authors’ Contributions;Funding Statement;Acknowledgements;Supplementary Materials;References;Appendix;Abbreviations;Preliminaries;Introduction and Preliminaries;Notation;Proof of Theorem;Proofs;Analysis of Results;Examples;Numerical Example;Applications;Numerical Simulation;Model;Model Formulation;Systematic Palaeontology;Nomenclatural Acts;Taxonomic Implications;Experimental;Synthesis;Overview;Characterization;Background;Experimental;Theories;Calculations;Model Verification;Model Implementation;Geographic location;Study Area;Geological setting;Data Collection;Field Testing;Data and Sampling;Dataset;Literature Review;Related Works;Related Work;System Model;Methods and Data;Experimental Results;Results and Analysis;Evaluation;Implementation;Case Presentation;Case Report;Search Terms;Case Description;Case Series;Background;Limitations;Additional Points;Case;Case 1;Case 2 etc.;Concern Details;Retraction Details;Copyright;Related Articles
摘要:
The influenza virus induces cellular apoptosis during viral propagation, and controlling this virus-induced apoptosis process has been shown to have significant antiviral effects. The proapoptotic BH3-only protein Noxa is a strong inducer of apoptosis that can be activated by this virus, suggesting that Noxa has the potential as an anti-influenza target. To assess the value of Noxa as an antiviral target, we utilized CRISPR/Cas9 technology to produce a Noxa-knockout cell line. We found that the knockout of Noxa resulted in a dramatic reduction in the cytopathic effect induced by the influenza virus. Moreover, Noxa knockout decreased the expression of influenza viral proteins (NP, M2, HA, and NS2). In addition, Noxa deficiency triggered a complete autophagic flux to weaken influenza virus-induced autophagosome accumulation, indicating that Noxa may be a promising antiviral target for controlling influenza virus infections.
期刊:
Journal of Hazardous Materials,2023年459:132262 ISSN:0304-3894
作者机构:
[Wang, Xu; Guo, Pu; Hu, Siyi; Lu, Qirong; Yang, Yaqin] National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China;[Guo, Pu; Hu, Siyi; Lu, Qirong; Yang, Yaqin] MAO Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei 430070, China;[Guo, Pu; Lu, Qirong] Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, China;[Wang, Xinru] College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China;[Yang, Xinzhou] School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, Hubei 430070, China. Electronic address: xzyang@mail.scuec.edu.cn
关键词:
Agonist;BBB;Daucosterol;PGC-1α;T-2 toxin
摘要:
T-2 toxin is a common environmental pollutant and contaminant in food and animal feed that represents a great challenge to human and animal' health throughout the world. Using natural compounds to prevent the detrimental effects of T-2 toxin represents an attractive strategy. Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a critical regulator in various cellular processes. Recently, PGC-1α activation has been reported to confer protection against neurological injuries. We aimed to identify a potent PGC-1α activator from plants as a chemopreventive compound and to demonstrate the efficacy of the compound in attenuating T-2 toxin-induced blood-brain barrier (BBB) toxicity. We identified daucosterol, which binds directly to the 71-74 (-1100 to -1000bp) position of the second promoter of human PGC-1α by hydrogen bonding. An in vitro and in vivo T-2 toxin induced BBB injury model revealed that this compound can protect against this injury by increasing transepithelial/transendothelial electrical resistance, reducing sodium fluorescein (NaF) infiltration and increasing the expression of tight junction-related proteins (zonula occludens-1 (ZO-1), occludin (OCLN), claudin-5 (CLDN5)) expression. In conclusion, we identified daucosterol as representing a novel of PGC-1α activators and illustrated the mechanism of specific binding site. Furthermore, we have demonstrated the feasibility of using natural compounds targeting PGC-1α as a therapeutic approach to protect humans from environmental insults that may occur daily such as lipopolysaccharide.
摘要:
Building heterojunctions is a promising strategy for the achievement of highly efficient photocatalysis. Herein, a novel SnIn4S8@ZnO Z-scheme heterostructure with a tight contact interface was successfully constructed using a convenient two-step hydrothermal approach. The phase composition, morphology, specific surface area, as well as photophysical characteristics of SnIn4S8@ZnO were investigated through a series of characterization methods, respectively. Methylene blue (MB) was chosen as the target contaminant for photocatalytic degradation. In addition, the degradation process was fitted with pseudo-first-order kinetics. The as-prepared SnIn4S8@ZnO heterojunctions displayed excellent photocatalytic activities toward MB degradation. The optimized sample (ZS800), in which the molar ratio of ZnO to SnIn4S8 was 800, displayed the highest photodegradation efficiency toward MB (91%) after 20 min. Furthermore, the apparent rate constant of MB photodegradation using ZS800 (0.121 min-1) was 2.2 times that using ZnO (0.054 min-1). The improvement in photocatalytic activity could be ascribed to the efficient spatial separation of photoinduced charge carriers through a Z-scheme heterojunction with an intimate contact interface. The results in this paper bring a novel insight into constructing excellent ZnO-based photocatalytic systems for wastewater purification.
摘要:
This research analyses the relative efficacy of gold price, financial market, and stock exchange hedging against sectoral and industry-level global stock market returns. Incorporating Gold into equity-based asset allocation techniques and assessing the stock market and financial sector during the COVID-19 epidemic is one way to diversify your portfolio and reduce risk. After orthogonalizing raw returns concerning a robust collection of relevant universal variables, we conduct our analysis inside a bivariate GARCH(p, q) framework. To further assess ideal portfolio proportions and the efficacy of hedging methods, we expand the volatility spillovers study by calculating the optimal weights for a minimal risk portfolio and determining the hedge ratio. In high-volatility environments, our results show which financial market and stock exchange sectors and industries investors should prioritize to minimize the risk and maximize reward. Use of country-specific macroeconomic variables indices to supplement the worldwide index, (3) separate analysis for the COVID-19 first wave due to the existing argument that the pandemic raises unexpected market events and our early data showing co-movement among the three unpredictability metrics during the pandemic. These findings have important implications for portfolio entrepreneurs and business investors looking to buy international equities.
通讯机构:
[Li, B ] W;Wuhan Polytech Univ, Sch Mech Engn, Wuhan 430023, Peoples R China.
关键词:
ribbed laminated cylinder shell;micro-perforated shell;acoustic radiation;finite element analysis
摘要:
In response to the problem of vibration and noise reduction in equipment with cylindrical shell structures, this paper focuses on the micro-perforated laminated cylindrical shell structure and establishes its finite element model. Through comparative analysis with experimental results, the reliability of the finite element modeling method is verified. Based on this, the paper places particular emphasis on the vibration and acoustic radiation performance of the structure in the 1–1000 Hz frequency range under free conditions to understand the impact of different laminated shell structures, micro-perforation parameters (porosity, aperture), sound-absorbing foam materials, and placement methods. The results indicate that micro-perforated structures can efficiently reduce the structural radiated sound power level at specific frequencies, but the overall reduction in radiated sound power level is not significant. Various types of foam are effective in reducing the structural radiation acoustic power level, with polyurethane performing best among them. Changing the location of foam placement has a relatively insignificant impact on the structural radiation acoustic power level.
摘要:
A 1 at% carbon non-equiatomic doped Co19Cr5Fe38Ni19Mn19 high-entropy alloy was synthesized by vacuum arc-melting in a high-purity argon atmosphere, followed by homogenization, cold rolling, and annealing under various conditions. The evolutions of microstructure and mechanical properties during annealing were systematically studied and compared with the carbon free alloy. Results showed that nano-sized fibrous deformation grains were formed in the 90% cold rolled alloys, resulting in high strength but low plasticity. Recovery sub-structures and recrystallized grains gradually formed with increasing annealing temperature, leading to a significant decrease in defect density, thereby softening the materials and increasing their plasticity. The early stage of recovery was mainly related to the migration of vacancy and interstitial carbon atoms, while dislocation climb became the main recovery mechanism in the late recovery stage. The carbon-doped alloy exhibited a higher recovery activation energy compared with the carbon free alloy. Therefore, 1 at% interstitial carbon effectively increased the recovery and recrystallization resistance of the Co19Cr5Fe38Ni19Mn19 alloy.& COPY; 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
作者机构:
[舒少华; 刘和平; 刘金鑫; 唐静; 苏振佳] College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China;[朱闻君] School of Biological and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan, 430023, China
通讯机构:
[Shu, S.-H.] C;College of Plant Science and Technology, China