摘要：
Nanomaterials are widely used as promising additives in tribology. In this study, large cadmium-based phosphate (CdP) microspheres assembled from nanosheets were synthesized, and the tribological performance and anti-wear mechanism of the CdPs as additives in lubricating oils were investigated using a reciprocating ball-on -disc tribometer and surface characterization techniques. Oxygen-free oil with CdP significantly reduced the friction coefficient (COF) and wear rate (WR) of TA5 titanium alloys. Compared with pure polyalphaolefin 8 (PAO8), lubrication with PAO8 containing 25 wt% CdP reduced the average COF and WR by 70.03 % and 99.56 %, respectively. The extraordinary anti-wear property was attributed to the adsorption and deposition of CdP on the titanium alloy surface through P-O-Ti bonds, which resulted in a smooth tribofilm containing CdP. This tribofilm can prevent the adhesion of debris from the titanium alloy on the worn surface of the alloy and reduce adhesive and abrasive wear. However, the adsorption of CdP on the titanium alloy was compromised when an oxygen-containing oil was used as the base oil because the oxygen-containing oil molecules can bind to the ti-tanium alloys and block the positions occupied by CdP. Based on the experimental results, it is concluded that CdP is an excellent anti-wear additive for titanium alloys.
摘要：
为研究汉江武汉市城区段水质变化对蚕豆根尖细胞的遗传毒性效应,于汉江流经武汉市东西湖区至其与长江的入江口之间设置水样采样点,采用蚕豆根尖微核技术,研究在不同水样胁迫下对蚕豆根尖的生长和对基因组 DNA 的遗传毒性效应.结果表明,与对照组蒸馏水相比,不同水样处理后均可显著抑制蚕豆根尖的生长速度,其对蚕豆根尖生长的抑制率范围为0.37%～0.75%;除样点 C 外,不同水样处理后根尖恢复生长速度与对照组均无显著差异.不同水样处理蚕豆根尖细胞后,在细胞有丝分裂的不同时期发现有染色体畸变和微核的形成.统计分析表明,不同水样可显著诱导蚕豆根尖细胞形成微核,且沿汉江至长江交汇处各样点水样处理组呈现微核率增加的趋势,其微核率范围在 0.85‰～1.81‰.汉江武汉市城区段水体存在一定的遗传毒性效应,其水质呈现轻度污染或轻度转至中度污染,临近人群密集集散地样点水体的污染程度较高,表明人类活动强度可对水体水质产生一定程度的影响.
期刊：
BioMed Research International,2023年2023:6540585 ISSN：2314-6133
通讯作者：
Yan Xiong<&wdkj&>Hongbo Cai<&wdkj&>Hongyu Zhang<&wdkj&>Feng Zhu<&wdkj&>Yang Xiang<&wdkj&>Rong Yan<&wdkj&>Xi Chen<&wdkj&>Xiaoyu Ke<&wdkj&>Shunmei Huang<&wdkj&>Weiran Ke<&wdkj&>Yu Han
作者机构：
[Xiong, Yan; Zhu, Feng; Yan, Rong; Cai, Hongbo; Han, Yu; Zhang, Hongyu; Xiang, Yang] School of Biological and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430030, China;[Ke, Weiran] College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China;[Chen, Xi] Department of Nosocomial Infection Management, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;[Huang, Shunmei] Department of Geriatrics, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China;[Ke, Xiaoyu] Emergency Department and Intensive Care Unit, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
关键词：
Introduction;Materials and Methods;Results;Discussion;Conclusion;Abstract;Data Availability;Additional Points;Ethical Approval;Consent;Disclosure;Conflicts of Interests;Authors’ Contributions;Funding Statement;Acknowledgements;Acknowledgments;Supplementary Materials;Reference;Dataset Description;Dataset Files;Abstract;Introduction;Introduction and Materials;Introduction and Methods;Materials;Materials and Methods;Methods;Results;Discussion;Results and Discussion;Discussion and Conclusion;Results and Conclusion;Conclusion;Conclusions;Data Availability;Additional Points;Ethical Approval;Consent;Disclosure;Conflicts of Interest;Authors’ Contributions;Funding Statement;Acknowledgements;Supplementary Materials;References;Appendix;Abbreviations;Preliminaries;Introduction and Preliminaries;Notation;Proof of Theorem;Proofs;Analysis of Results;Examples;Numerical Example;Applications;Numerical Simulation;Model;Model Formulation;Systematic Palaeontology;Nomenclatural Acts;Taxonomic Implications;Experimental;Synthesis;Overview;Characterization;Background;Experimental;Theories;Calculations;Model Verification;Model Implementation;Geographic location;Study Area;Geological setting;Data Collection;Field Testing;Data and Sampling;Dataset;Literature Review;Related Works;Related Work;System Model;Methods and Data;Experimental Results;Results and Analysis;Evaluation;Implementation;Case Presentation;Case Report;Search Terms;Case Description;Case Series;Background;Limitations;Additional Points;Case;Case 1;Case 2 etc.;Concern Details;Retraction Details;Copyright;Related Articles
摘要：
BACKGROUND: Both high-fat diet (HFD) and 4-nonylphenol (4-NP) could affect fat formation in adipose tissue individually. We investigated whether HFD promote abnormal adipose tissue formation caused by early exposure to 4-NP in life and preliminarily explore the possible mechanisms involved. METHODS: The first-generation rats were treated with HFD on postnatal day after pregnant rats exposure to 5 ug/kg/day 4-NP. Then, the second generation rats started to only receive normal diet without 4-NP or HFD. We analyzed organ coefficient and histopathology of fat tissues, biochemical index, and gene level involved in lipid metabolism in female offspring rats. RESULTS: HFD and 4-NP interaction synergistically increased birth weight, body weight, and organ coefficients of adipose tissue in offspring female rats. HFD accelerately aggravated abnormal lipid metabolism and increased the adipocyte mean areas around the uterus of the offspring female rats induced by prenatal exposure to 4-NP. HFD also facilitate the regulation of gene expression involved lipid metabolism in offspring female rats induced by perinatal exposure to 4-NP, even passed on to the second generation of female rats. Moreover, HFD and 4-NP interaction synergistically declined the gene and protein expression of estrogen receptor (ER) in the adipose tissue of second-generation female rats. CONCLUSION: HFD and 4-NP synergistically regulate the expression of lipid metabolism genes in adipose tissue of F2 female rats and promote adipose tissue generation, leading to obesity in offspring rats, which is closely related to low expression of ER. Therefore, ER genes and proteins may be involved in the synergistic effect of HFD and 4-NP.
作者：
Bi, Kai;Liang, Yong;Mengiste, Tesfaye;Sharon, Amir
期刊：
Trends in Plant Science,2023年28(2):211-222 ISSN：1360-1385
通讯作者：
Amir Sharon
作者机构：
[Bi, Kai] Wuhan Polytech Univ, Coll Life Sci & Technol, Wuhan, Hubei, Peoples R China.;[Liang, Yong; Sharon, Amir] Tel Aviv Univ, Fac Life Sci, Sch Plant Sci & Food Secur, IL-69978 Tel Aviv, Israel.;[Mengiste, Tesfaye] Purdue Univ, Dept Bot & Plant Pathol, 915 West State St, W Lafayette, IN 47907 USA.
通讯机构：
[Amir Sharon] S;School of Plant Sciences and Food Security, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
摘要：
豆甾醇是来源于食物中的一种植物不饱和甾醇,在胃癌防治中展现出良好的应用前景。基于网络药理学探讨豆甾醇抗胃癌的作用靶点及分子机制。借助PharmMapper数据库得到药物相关靶点,通过疾病数据库Genecard和OMIM(...展开更多 豆甾醇是来源于食物中的一种植物不饱和甾醇,在胃癌防治中展现出良好的应用前景。基于网络药理学探讨豆甾醇抗胃癌的作用靶点及分子机制。借助PharmMapper数据库得到药物相关靶点,通过疾病数据库Genecard和OMIM(Online Mendelian Inheritance in Man)获得胃癌相关靶点;对潜在标靶进行GO(Gene Ontology)、KEGG(Kyoto Encyclopedia of Genes and Genomes)富集分析得到相关作用通路;随后,利用STRING数据库分析治疗靶点之间蛋白的相互作用,借助Cytoscape3.8.0中CytoHubba插件构建蛋白质相互作用网络以获得Hub基因,预测豆甾醇抗胃癌的作用靶点及机制。借助数据库得到豆甾醇潜在胃癌治疗靶点19个,涉及77个生物过程与10条信号通路;通过蛋白互作网络取排名前5的Hub基因,分别为TERT、MET、SRC、MDM2、HIF1A。结果显示,网络药理学可以准确预测豆甾醇抗胃癌的作用靶点并揭示其分子机制与PI3K(Phosphatidylinositide 3-kinases)/AKT(蛋白激酶B)和RAS(Rat Sarcoma)通路上TERT、MET、SRC、MDM2、HIF1A这些关键基因的表达有关。收起
摘要：
The spoilage potential of three dominant bacterial species (Shewanella putrefaciens, Pseudomonas fragi, and Acinetobacter sp.), which were isolated from spoiled yellow catfish, were investigated. Physicochemical properties, moisture distribution, and volatile flavor compounds were assessed in yellow catfish inoculated with individual bacterial species. Compared to Acinetobacter sp., Shewanella putrefaciens and Pseudomonas spp. exhibited a greater capacity for producing produce total volatile basic nitrogen (TVB-N) and total viable counts. Sensory results revealed that a significantly (P < 0.05) higher b* value in yellow catfish group inoculated with Shewanella putrefaciens compared to other groups, resulting in discoloration. Low-field nuclear magnetic imaging results indicated a decline in the proportion of bound and free waterof during extended storage, accompanied by an increase in immobilized water. The yellow catfish group inoculated with Shewanella putrefaciens exhibited the lowest P-23 and the highest T-23, which indicated Shewanella putrefaciens changed the water holding capacity of fish samples. Gas chromatography-ion mobility spectrometry (GC-IMS) analysis of volatile flavor compounds demonstrated the pronounced capability of Pseudomonas fragi to generate 1-octen-3-ol, closely associated with ketones production and contributing significantly to the odor of yellow catfish during spoilage. In addition, E. coli was found to have the ability to spoil yellow catfish and generate unfavorable volatile flavor compounds. This research enhances the comprehension of yellow catfish spoilage and preservation.
通讯机构：
[Hongxun Wang] H;Hubei Key Laboratory for Processing and Transformation of Agricultural Products, Wuhan Polytechnic University, Wuhan 430023, China<&wdkj&>School Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, China<&wdkj&>Author to whom correspondence should be addressed.
摘要：
Browning limits the commercial value of fresh-cut lotus root slices. Melatonin has been reported to play crucial plant roles in growth and development. However, the mechanisms in repressing the browning of fresh-cut lotuses are still unclear. In this study, fresh-cut lotus root slices were treated with melatonin, the physical signs of browning were tested, and then the selected samples (0 d, 6 d, 12 d) were used in multiomics analysis. Fresh-cut lotus root slices with a thickness of 4 mm were soaked in a 40 mmol/L melatonin solution for 10 min; then, the slices were packed in pallets and packages and stored at 10 +/- 1 degrees C. The results show that the 40 mmol/L melatonin selected for repressing the browning of lotus roots significantly delayed the decrease in water, total soluble solid content, and Vitamin C, decreased the growth of microorganisms, enhanced total phenolic content, improved total antioxidant capacity, and decreased center dot OH, H2O2, and O-2(-)center dot contents. Moreover, this treatment enhanced phenylalanine ammonialyase, polyphenol oxidase, superoxide dismutase, and catalase activities and reduced peroxidase activities and soluble quinones. NnSOD (104590242), NnCAT (104609297), and some NnPOD genes showed a similar transcript accumulation pattern with enzyme activity. It can be seen from these results that exogenous melatonin accelerated an enhancement in the antioxidant system and AsA-GSH cycle system by regulating ROS-metabolism-related genes, thereby improving the capacity to withstand browning and the quality of lotus root slices. The microbiome also showed that melatonin suppressed the fertility of spoilage organisms, such as Pseudomonas, Tolumonas, Acinetobacter, Stenotrophomonas, and Proteobacteria. Metabonomics data uncovered that the metabolites of flavonoid biosynthesis, phenylpropanoid biosynthesis, tyrosine metabolism, and phenylalanine metabolism were involved in the process.
