通讯机构：
[Lian Zhu; Ben-Mei Wei] S;School of Chemical and Environmental Engineering, Wuhan Polytechnic University, Changqing Garden, Wuhan, 430023 Hubei, China
通讯机构：
[Liu, Y ] W;[Li, L ] H;Huanggang Normal Univ, Coll Chem & Chem Engn, Hubei Key Lab Proc & Applicat Catalyt Mat, Huanggang 438000, Peoples R China.;Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan 430023, Peoples R China.;Hubei Univ Sci & Technol, Hubei Key Lab Radiat Chem & Funct Mat, Xianning 437100, Peoples R China.
摘要：
Diseases such as liver cancer, extrahepatic biliary obstruction and osteocarcinoma are closely associated with the abnormal level of alkaline phosphatase (ALP). Hence, it is essential to develop a convenient assay to detect ALP activity. Herein, a novel signal-on fluorescent biosensor on account of the fluorescence signal of the aggregation-induced emission (AIE) fluorochrome 2,2 ',2 '',2 '''-((ethene-1,1,2,2-tetrayltetrakis(benzene-4,1-diyl))tetrakis(oxy))tetraacetic acid (EBTAC) encapsulated zeolitic imidazolate framework-8 (ZIF-8@EBTAC) was designed to monitor ALP. Due to the aggregation-induced emission of EBTAC, the synthetic ZIF-8@EBTAC shows robust fluorescence. Once pyrophosphate (ppi) was added, its complexation with Zn2+ in ZIF-8 triggered the collapse of the ZIF-8 framework, releasing encapsulated EBTAC molecules and restoring to free state, leading to the dramatical decrease in fluorescence. ALP could catalyze the hydrolysis of ppi to phosphate (pi), which is difficult to bind to Zn2+ and has little effect on the fluorescence of ZIF-8@EBTAC. Therefore, with the assistance of the substrate ppi, the ultimate fluorescence of ZIF-8@EBTAC was positively related with ALP activity. The constructed biosensor was able to monitor the ALP activity well from 0.01 to 100 U L-1, and a detection limit of 0.01 U L-1 was achieved. Based on the ability of EBTAC serving as a fluorescent probe with aggregation-induced luminescence properties, this proposed design can be applied to diverse targets and provide new ideas for the establishment of fluorescent biosensors. A signal-on fluorescence biosensing platform for detection of alkaline phosphatase was developed based on self-assembly aggregation-induce emission fluorochrome ZIF-8@EBTAC.
摘要：
Cellulose acetate oleate (CAO)-reinforced poly(butylene adipate-co-terephthalate) (PBAT) composites were prepared by the solvent casting method. The influence of the addition of CAO on the mechanical property, thermal property, disintegration property, compatibility, and hydrophobicity of PBAT/CAO composites was investigated. Compared with PBAT, the tensile strength and Young's modulus of PBAT/CAO with 4 wt% CAO were increased by 9.5% and 25.7%, and the disintegration rate was also increased by 2.8 times. The results of morphological property, contact angle, and water vapor transmission indicated that the PBAT/CAO composites had good interfacial interaction and compatibility, and the hydrophobicity was improved. PBAT/CAO was applied to strawberry preservation, and it showed excellent freshness retention performance. Moreover, a possible degradation pathway for PBAT/CAO composite was proposed. This work provided a way for the preparation and performance improvement of biodegradable materials, which is expected to be applied in the packaging field.
摘要：
Surface modification is one of the most important approach for improving the reactivity of zero-valent iron. In this study, waste coffee grounds (CG) were chosen to modify zero-valent iron through a mechanochemical method. The synthesized CG-ZVI exhibited a 166 times faster Cr(VI) removal rate. Structural characterization and ATR-FTIR analysis indicated that CG modification endowed ZVI with abundant carboxylic acid groups, and accelerated the adsorption of Cr(VI) via the complexation effect of CG-COOH center dot center dot center dot HCrO4 � . Moreover, the polyphenolic substances from CG-ZVI, as an electron shuttle, accelerated the electron transfer from the iron core to generated surfaced bound Fe2+, resulting in high efficiency of Cr(VI) removal. In addition, CG-ZVI selectively removed Cr(VI) in the presence of anions (Cl- , NO3 � , SO4 2 � ) and acted as a permeable reactive barrier material for in situ treatment of heavy metal-contaminated water. This work demonstrates that CG modification can function as an excellent candidate for perfecting the reactivity of ZVI. More importantly, it opens up a new way for the utilization of discarded CG.
摘要：
In order to explore the influence of molecular structure on the properties of liquid crystal (LC) materials, the dielectric anisotropy, rotational viscosity coefficient and birefringence of different fluorine-containing polyphenyl LC compounds are measured experimentally. The effects of lateral substituents and terminal substituents are analyzed. The experimental results show that the substitution of fluorine substituents in lateral substituents or terminal substituents will lead to the decrease of rotational viscosity coefficient, whether it is fluorine-containing triphenyl LC compounds or fluorine-containing tetraphenyl LC compounds. The dielectric anisotropies of LC compounds (fluorine-containing tetraphenyl LC compounds ND-3 and ND-8, ND-4 and ND-9, and ND-1 and ND-10) in which the terminal isothiocyano substituents are substituted by fluorine substituents all show a downward trend, with the decreasing degrees of 41.3%, 20.7% and 19.2% respectively. In addition to the influence of the replacement of fluorine and isothiocyanato on the terminal substituents, the dielectric anisotropy is affected by different lateral substituents from large to small: fluorine, methyl, and ethyl. The lateral fluorine substitution impact of ND-3, with an increase of 9.4%, is the best among fluorine-containing tetraphenyl LC compounds when compared to the lateral ethyl substitution of ND-2. Besides, compared with -F, -NCS can effectively extend the pi-electron conjugation length of the molecule and improve the birefringence of the LC. This research is of great help to improve the comprehensive properties of LC materials and provides data accumulation for the development and application of LC compounds.
摘要：
RNA-based nanomedicines encompass a range of therapeutic approaches that utilize RNA molecules or molecules that target RNAs for the treatment or prevention of diseases. These include antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), endogenous microRNAs (miRNAs), messenger RNAs (mRNAs), clustered regularly interspersed short palindromic repeats-associated protein 9 (CRISPR/Cas9), single guide RNAs (sgRNAs), as well as RNA aptamers. These therapeutic agents exert their effects through various mechanisms such as gene inhibition, addition, replacement, and editing. The advancement of RNA biology and the field of RNA therapy has paved the way for the development and utilization of RNA-based nanomedicine in human healthcare. One remarkable example of RNA-based nanomedicine is the mRNA-based vaccines including mRNA-1273 (Moderna) and BNT162b2 (Pfizer/BioNTech) that have been successfully employed in response to the coronavirus disease 2019 (COVID-19) pandemic. This review aims to highlight the advantages of RNA-based nanomedicines, provides an overview of significant developments in delivery systems, elucidates the molecular mechanisms of action underlying RNA-based nanomedicines, and discusses their clinical applications. Additionally, the review will address the existing challenges and innovations in delivery platforms while exploring the future possibilities for these promising RNA-based nanomedicines.
摘要：
To improve the utilization efficiency of renewable energy and adaptability of composite materials, a new mineral-based composite phase change material (Ag-Mica/CNF/PW) was designed and prepared by chemically modifying natural mica, attaching silver nanoparticles to the mica surface as functionalized support material, and using paraffin wax as the phase change functional medium. As expected, the thermal conductivity of the composite phase change material (CPCMs) increased significantly to 0.9 W/m k, which was 330.1% higher relative to pure paraffin. With the addition of silver-modified mica, the volume resistivity of CPCMs reached 11.9 x 1012 X cm. The relative enthalpy efficiency achieved 104.8%, and the photothermal conversion efficiency reached 91.3%, proving that the silver-modified mica-based CPCM was successful and feasible. The heat resistance index of CPCMs was 137.2 degrees C, and the enthalpy loss rate after 50 cycles was only 0.7 %, indicating that CPCMs have excellent thermal stability. The designed CPCMs are a promising candidate for developing thermal storage and building thermal management, electrical insulation and solar energy conversion.(c) 2023 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
作者机构：
[Zhong, Huaying; Zhang, Yi; Chen, Jinhang; Zhu, Hao; Zheng, Mingming] Chinese Acad Agr Sci, Oil Crops Res Inst, Hubei Key Lab Lipid Chem & Nutr, Hubei Hongshan Lab,Key Lab Oilseeds Proc,Minist Ag, Wuhan 430062, Peoples R China.;[Wang, Hongxun; Chen, Jinhang; Zheng, Mingming] Wuhan Polytech Univ, Sch Life Sci & Technol, Wuhan 430023, Hubei, Peoples R China.;[Goh, Kheng-Lim] Newcastle Univ Singapore, 172A Ang Mo Kio Ave 8 05-01, Singapore 599493, Singapore.;[Zhang, Juntao] Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan 430023, Hubei, Peoples R China.
通讯机构：
[Yi Zhang; Mingming Zheng] O;Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Hubei Key Laboratory of Lipid Chemistry and Nutrition, Hubei Hongshan Laboratory, Key Laboratory of Oilseeds Processing, Ministry of Agriculture, Wuhan, 430062, China<&wdkj&>Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Hubei Key Laboratory of Lipid Chemistry and Nutrition, Hubei Hongshan Laboratory, Key Laboratory of Oilseeds Processing, Ministry of Agriculture, Wuhan, 430062, China<&wdkj&>School of Life Science and Technology, Wuhan Polytechnic University, Wuhan, Hubei, 430023, China
摘要：
Green and effective synthesis of flavor esters is a long-term interest in food, cosmetic and pharmaceutical in-dustries. Here, an immobilized lipase microarray was prepared by immobilizing lipase CSL on hydrophobically modified ordered mesoporous silicon (CSL@OMS-C-8) for the enzymatic production of cinnamic esters with different flavors. The results showed that the CSL@OMS-C-8, with an immobilization capacity of 249.3 +/- 11.1 mg/g, exhibited 1.6 times higher catalytic activity than that of free lipase at the optimum temperature of 70 degrees C. The maximum yield of benzyl cinnamate reached 97.3% in 2 h with the corresponding CE value of 650.5 mu mol/g center dot h, leading to the highest record compared to the current literature. Besides, the CSL@OMS-C-8 could maintain 81.4 +/- 1.1% conversion for cinnamic acid after five-cycle reuse, thus revealing the high stability and reusability of immobilized lipase. Finally, the broad applicability of the immobilized lipase microarray was confirmed by its capacity to successfully catalyze the synthesis of methyl cinnamate, ethyl cinnamate, butyl cinnamate, geranyl cinnamate and isoamyl cinnamate. This study reveals new insights on the efficient and sustainable enzymatic approach to produce natural cinnamic acid flavor esters and, consequently, could pave the way for the natural and clean production in food industries.
关键词：
Tubular NiCo 2 S 4;Electrode materials;Lithium sulfur batteries;Electrochemical performance
摘要：
Tubular nickel and cobalt bimetal sulfides NiCo2S4 hierarchical architectures were fabricated by a facile solvothermal method and investigated electrochemically as sulfur hosts for lithium sulfur batteries compared to bare sulfur. The results indicated that the single/double-walled tubular NiCo2S4 could be tuned to assemble the hierarchical architectures consisting of the nanoparticles, their electrochemical performances as sulfur hosts for lithium sulfur batteries are exhibited differently with respect to the host morphology and even compared to those of bare sulfur as well. Comparatively, the double-walled tubular NiCo2S4 hierarchical architecture as sulfur host for lithium sulfur batteries delivers a higher initial specific capacity of as high as 1078.9 mAh g-1, and exhibits better cyclability and rate capability, which might be ascribed to even dispersion of sulfur over the electrically conductive double-walled tubular NiCo2S4 hierarchical architecture, thus facilitating the full utilization of sulfur and the fast redox reaction kinetics of lithium polysulfides. In a word, bimetal sulfide NiCo2S4 are promising as sulfur host for the industrial implementation of lithium sulfur batteries, dependent of its optimization on morphology and structure.
通讯机构：
[Wu, K; Liu, Y ; Zhao, Y ] ;Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Hubei Prov Coal Convers & New Carbon Mat, Wuhan 430081, Peoples R China.;Chinese Acad Sci, Inst Chem, Natl Ctr Mass Spectrometry Beijing, Beijing Natl Lab Mol Sci,CAS Key Lab Analyt Chem L, Beijing 100190, Peoples R China.;Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan 430023, Peoples R China.
摘要：
The interaction of a photoactivatable diazidodihydroxido Pt(IV) prodrug, trans,trans,trans-[Pt(N(3))(2)(OH)(2)(py)(2)] (py = pyridine; 1), with a hexamer straight human telomeric DNA unit sequence (5'-T(1)T(2)A(3)G(4)G(5)G(6)-3', I) upon light irradiation was investigated by electrospray ionization mass spectroscopy (ESI-MS). In the primary mass spectrum, two major mono-platinated I adducts with the bound Pt moieties, trans-[Pt(II)(N(3))(py)(2)](+) (1') and trans-[Pt(II)(py)(2)](2+) (1''), respectively, were detected. It is rare to observe such high abundance and nearly equal intensity platinated DNA adducts formed by these two Pt(II) species because 1' is usually the only major reduced Pt(II) species produced by the photodecomposition of complex 1 in the presence of DNA while 1'' was rarely detected as the major reduced Pt(II) species reported previously. Subsequent tandem mass spectrometric analysis by collision-induced dissociation (CID) showed that in the former adduct {I + 1'}(2+), G(6) and A(3) were the platination sites. While in the latter adduct {I + 1''}(2+), a potential intrastrand crosslink was speculated after G(4) and G(6) sites were identified. Additionally, other minor platinated adducts like di-platinated I adduct by 1' with platination sites at G(4) and G(6) and mono-platinated I adducts containing base oxidation were also detected by mass spectrometry. Due to the rich guanines and their sensitivity to oxidation, the oxidation induced by 1 most probably occurred at guanine. The oxidation adducts were proposed as 8-hydroxyl guanine, spiroiminodihydantoin (Sp), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG), 5-guanidinohydantoin (Gh), and/or dehydroguanidinohydantoin (DGh) referring to previous reports. The obtained results provide useful chemical information about the photoreaction between photoactivatable Pt(IV) anticancer prodrugs and human telomeric DNA. Such special damages of Pt(IV) prodrugs on human telomeric DNA implicate its active role in the mechanism of Pt(IV) prodrugs and further support the unique sequence-dependent photointeraction profile of complex 1 reacting with DNA.
摘要：
Polymer based protein engineering provides an attractive strategy to endow novel properties to protein and overcome the inherent limitations of both counterparts. The exquisite control of site and density of attached polymers on the proteins is crucial for the bioactivities and properties of the protein-polymer bioconjugates, but is still a challenge. Collagen is the major structural protein in extracellular matrix of animals. Based on the advancements of polymer-based protein engineering, collagen bioconjugates has been widely fabricated and applied as biomaterials. However, the site-specific synthesis of well-defined collagen-polymer bioconjugates is still not achieved. Herein, a versatile strategy for the specific modification of N-terminal α-amino groups in collagen was developed. Firstly, all reactive amino groups of tropocollagen (collagen with telopeptides) were protected by succinic anhydride. Then, the telopeptides were digested to give the active N-terminal α-amino groups, which were subsequently attached with poly(N-isopropylacrylamide) (PNIPAAm) via "grafting from" method based on the atom transfer radical polymerization (ATRP). The site-specific N-terminal PNIPAAm modified succinylated collagen was prepared and its structure, thermal responsive behaviour, and properties was explored.
摘要：
Stem cells possess the capability of self-renewal and multipotency, which endows them with great application potential in wound repair fields. Yet, several problems including immune concerns, ethical debates, and oncogenicity impede the broad and deep advance of stem cell-based products. Recently, owing to their abundant resources, excellent biocompatibility, and ease of being engineered, stem cell-derived exosomes were proved to be promising nanomedicine for curing chronic wounds. What is more, stem cell-derived exosomes are almost the mini record of their maternal cells, which even equipped them with the unique characteristics of stem cells. Chronic wound healing efficacy is dominated by several complicated factors, especially the excessive inflammation conditions and impaired vessels. Therefore, this review tries to concentrate on the current advances of stem cell-derived exosomes for reducing inflammation and promoting angiogenesis in chronic wound healing processes. Last but not least, the existing limitations and future perspectives of stem cell-derived exosomes for chronic wound treatment are also outlined.
