摘要：
BACKGROUND: Social participation (SP) may be an effective measure for decreasing frailty risks. This study investigated whether frequency and type of SP is associated with decreased frailty risk among Chinese middle-aged and older populations. METHODS: Data were derived from the China Health and Retirement Longitudinal Study (CHARLS). Frailty was assessed using the Rockwood's Cumulative Deficit Frailty Index. SP was measured according to frequency (none, occasional, weekly and daily) and type (interacting with friends [IWF]; playing mah-jong, chess, and cards or visiting community clubs [MCCC], going to community-organized dancing, fitness, qigong and so on [DFQ]; participating in community-related organizations [CRO]; voluntary or charitable work [VOC]; using the Internet [INT]). Smooth curves were used to describe the trend for frailty scores across survey waves. The fixed-effect model (N = 9,422) was applied to explore the association between the frequency/type of SP and frailty level. For baseline non-frail respondents (N = 6,073), the time-varying Cox regression model was used to calculate relative risk of frailty in different SP groups. RESULTS: Weekly (β = - 0.006; 95%CI: [- 0.009, - 0.003]) and daily (β = - 0.009; 95% CI: [- 0.012, - 0.007]) SP is associated with lower frailty scores using the fixed-effect models. Time-varying Cox regressions present lower risks of frailty in daily SP group (HR = 0.76; 95% CI: [0.69, 0.84]). SP types that can significantly decrease frailty risk include IWF, MCCC and DFQ. Daily IWF and daily DFQ decreases frailty risk in those aged < 65years, female and urban respondents, but not in those aged ≥ 65years, male and rural respondents. The impact of daily MCCC is significant in all subgroups, whereas that of lower-frequent MCCC is not significant in those aged ≥ 65years, male and rural respondents. CONCLUSION: This study demonstrated that enhancing participation in social activities could decrease frailty risk among middle-aged and older populations, especially communicative activities, intellectually demanding/engaging activities and community-organized physical activities. The results suggested very accurate, operable, and valuable intervening measures for promoting healthy ageing.
作者机构：
[Jia X.; Hongyan W.] Department of Gynecology, Women′s Hospital School of Medicine Zhejiang University, Hangzhou, 310000, China;[Wenjuan Z.] College of Health Science and Nursing, Wuhan Polytechnic University, Wuhan, 430000, China;[Yonghong H.] Department of Oncology, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China
通讯机构：
[Hongyan, W.] D;Department of Gynecology, China
期刊：
Journal of Psychosocial Nursing and Mental Health Services,2021年59(11):18-+ ISSN：0279-3695
通讯作者：
Tan, Lingling
作者机构：
[Kong, Chan] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Nursing, Tongji Med Coll, Wuhan, Peoples R China.;[Zhang, Juan; Wang, Zhimin; Tan, Lingling] Univ South China, Dept Nursing, Hosp 2, 35 Jiefang Ave, Hengyang 421000, Hunan, Peoples R China.;[Gao, Xudong] Wuhan Polytech Univ, Coll Hlth Sci & Nursing, Wuhan, Peoples R China.;[Fan, Hongru] First Hosp Wuhan, Dept Cardiovasc Dis, Wuhan, Peoples R China.;[Wang, Jing] Fourth Hosp Wuhan, Dept Neurosurg, Wuhan, Peoples R China.
通讯机构：
[Tan, Lingling] U;Univ South China, Dept Nursing, Hosp 2, 35 Jiefang Ave, Hengyang 421000, Hunan, Peoples R China.
摘要：
This is the first study to assess nurses' attitudes and skills regarding grief counseling for bereaved family members of patients who died from coronavirus disease 2019 (COVID-19) in Wuhan, China. Using a cross-sectional design, 412 nurses selected through convenience sampling completed a demographic characteristics survey, Attitudes of Grief Counseling Scale, (AGCS) and Skills of Grief Counseling Scale (SGCS). Average AGCS score was 32.89 (SD = 9.46), with an overall percentage rate score of 65.6%. Factors influencing attitudes toward grief counseling included other grief counseling skills, educational level, communication skills, and training related to grief counseling (p < 0.05). Average SGCS score was 18.81 (SD = 4.25), with an overall percentage rate score of 58.7%. Factors influencing skills of grief counseling included responsibilities and roles, frequency of contact with the bereaved, and positive view of grief counseling (p < 0.05). Nurses' attitudes and skills regarding grief counseling were low, indicating an urgent need to improve grief counseling.
作者机构：
[高旭东] College of Health Science and Nursing, Wuhan Polytechnic University, Wuhan, 430023, China;[王震坤] Research Office, Tongji Hospital, Tongji Medical College of HUST, Wuhan, 430030, China;[孔婵] General Medical Department, Tongji Hospital, Tongji Medical College of HUST, Wuhan, 430030, China;[王四美] Department of Spine Surgery, Affiliated Nanhua Hospital, University of South China, Hengyang, 421000, China
通讯机构：
[Wang, S.] D;Department of Spine Surgery, China
作者机构：
[Li, Shang-Ze; Huang, Xi-Cheng; Zhang, Xiao-Dong; Li, Chao; Du, Run-Lei; Chen, Jie] Wuhan Univ, Coll Life Sci, Hubei Key Lab Cell Homeostasis, Wuhan 430072, Hubei, Peoples R China.;[Li, Shang-Ze; Song, Xue-Min] Wuhan Univ, Res Ctr Anesthesiol & Crit Care Med, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China.;[Liu, Wenbin] Wuhan Polytech Univ, Coll Hlth Sci & Nursing, Wuhan 430023, Hubei, Peoples R China.
通讯机构：
[Xue-Min Song] R;[Run-Lei Du] H;Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei Province, 430072, PR China<&wdkj&>Research Centre of Anesthesiology and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, 430071, PR China
摘要：
PURPOSE: To explore the relationship between Mycoplasma hyorhinis infection and tyrosine kinase inhibitor (TKI) resistance in lung adenocarcinoma patients. METHODS: Mycoplasma hyorhinis infection can be verified with the monoclonal antibody PD4, which specifically recognizes a distinct protein of M. hyorhinis. Immunohistochemistry (IHC), using PD4 to detect M. hyorhinis, was performed on paraffin-embedded lung adenocarcinoma tissues of patients who had epidermal growth factor (EGFR) mutations and had received oral TKI. The number of patients enrolled in our study was 101. Assessments following TKI treatment were performed until objective disease progression or stable disease at the cutoff date was reached. In all of the patients, the primary endpoint was investigator-assessed progression-free survival (PFS). RESULTS: Immunohistochemistry revealed that 61 of 101 cases (60.4%) of lung adenocarcinoma were positive for M. hyorhinis, which comprised of 31 low-positive cases and 30 high-positive cases; the remaining 40 cases (39.6%) were negative. The median PFS was significantly longer in the negative group [18months (95% CI 14.15-21.85)] than in the low-positive group [10months (95% CI 7.70-12.30); hazard ratio (HR) 4.095, 95% CI 2.254-7.438; p < 0.001] and in the high-positive group [4months (95% CI 2.85-5.15); HR 31.703, 95% CI 14.425-69.678; p < 0.001]. The results of the subgroup analysis were satisfactory. The PFS benefit with negative M. hyorhinis infection was consistent across subgroups. CONCLUSIONS: In this retrospective, exploratory analysis, M. hyorhinis infection significantly reduced PFS. With increased levels of M. hyorhinis infection, the progression of the disease was more advanced, likely due to the hydrolysis of TKI by M. hyorhinis. A strong correlation was found between M. hyorhinis infection and TKI resistance in lung adenocarcinoma. This study provides potent evidence that M. hyorhinis hydrolyses TKI and will assist in the research of related mechanisms in the future. IMPLICATIONS FOR CANCER SURVIVORS: It provides an option to improve the efficacy of TKI, including strategies to decrease M. hyorhinis infection, thereby reducing long-term distress in TKI resistance patients with EGFR mutations.
