Glycine relieves intestinal injury by maintaining mtor signaling and suppressing AMPK, TLR4, and NOD signaling in weaned piglets after lipopolysaccharide challenge

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xu, Xiao;Wang, Xiuying;Wu, Huanting;Zhu, Huiling;Liu, Congcong;...

通讯作者：

Liu, Yulan

作者机构：

[Wu, Huanting; Liu, Congcong; Xu, Xiao; Liu, Yulan; Hou, Yongqing; Wang, Xiuying; Zhu, Huiling] Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.

[Dai, Bing; Liu, Xiuting] Zhe Jiang Goshine Test Technol Co Ltd, Hangzhou 310030, Zhejiang, Peoples R China.

通讯机构：

[Liu, Yulan] W

Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.

语种：

英文

关键词：

adenosine triphosphate;glycine;iron;lipopolysaccharide;mammalian target of rapamycin;messenger RNA;rapamycin;sodium chloride;toll like receptor 4;zinc;AMP-activated protein kinase kinase;glycine;lipopolysaccharide;protein kinase;target of rapamycin kinase;toll like receptor 4;animal experiment;animal model;Article;colitis;controlled study;diet supplementation;Escherichia coli;gene expression;immunoblotting;inflammation;intestine injury;nonhuman;protein degradation;protein expression;real time polymerase chain reaction;RNA extraction;signal transduction;Western blotting;animal;drug effect;genetics;ileum;immunology;intestine mucosa;intraperitoneal drug administration;jejunum;metabolism;pathology;pig;weaning;Animals;Escherichia coli;Glycine;Ileum;Inflammation;Injections, Intraperitoneal;Intestinal Mucosa;Jejunum;Lipopolysaccharides;Models, Animal;Protein Kinases;RNA, Messenger;Swine;Toll-Like Receptor 4;TOR Serine-Threonine Kinases;Weaning

期刊：

International Journal of Molecular Sciences

ISSN：

1661-6596

年：

2018

卷：

期：

页码：

1980

DOI：

10.3390/ijms19071980

基金类别：

Acknowledgments: This study was financially supported by the State’s Key Project of Research and Development Plan (2016YFD0501210), the National Natural Science Foundation of China (31772615), the Project of the Hubei Provincial Department of Education (T201508), and the Project of Hangzhou Qianjiang Distinguished Expert (3122).

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

This study was conducted to envaluate whether glycine could alleviate Escherichia coli lipopolysaccharide (LPS)-induced intestinal injury by regulating intestinal epithelial energy status, protein synthesis, and inflammatory response via AMPK, mTOR, TLR4, and NOD signaling pathways. A total of 24 weanling piglets were randomly allotted to 1 of 4 treatments: (1) non-challenged control; (2) LPS-challenged control; (3) LPS + 1% glycine; (4) LPS + 2% glycine. After 28 days feeding, piglets were injected intraperitoneally with saline or LPS. The pig...

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Glycine relieves intestinal injury by maintaining mtor signaling and suppressing AMPK, TLR4, and NOD signaling in weaned piglets after lipopolysaccharide challenge

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