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A-type procyanidins from litchi pericarp ameliorate hyperglycaemia by regulating hepatic and muscle glucose metabolism in streptozotocin (STZ)-induced diabetic mice fed with high fat diet

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成果类型:
期刊论文
作者:
Li, Xiaopeng;Sui, Yong;Li, Shuyi;Xie, Bijun;Sun, Zhida*
通讯作者:
Sun, Zhida
作者机构:
[Sui, Yong; Sun, Zhida; Xie, Bijun; Li, Xiaopeng] Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Peoples R China.
[Li, Shuyi] Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Peoples R China.
通讯机构:
[Sun, Zhida] H
Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Peoples R China.
语种:
英文
关键词:
A-type procyanidins;Diabetes;Hypoglycaemic effect;Litchi pericarp
期刊:
Journal of Functional Foods
ISSN:
1756-4646
年:
2016
卷:
27
页码:
711-722
基金类别:
National Key Technologies Program of China [2012BAD31B03]
机构署名:
本校为其他机构
院系归属:
食品科学与工程学院
摘要:
A-type procyanidins is rich in litchi pericarp. This study evaluated the prevention and anti diabetic effect of A-type oligomeric procyanidins (A-OPC). The results showed A-OPC was more effective than B-type oligomeric procyanidins (B-OPC) of lotus seedpod. AMP activated protein ldnase (AMPK) was activated in liver and skeletal muscle. The protein levels of glucokinase (GK), glucose transporter type 2 (GLUT2, in liver), glucose transporter type 4 (GLUT4, in skeletal muscle) and insulin receptor a (INSR) improved significantly with treatment of A-OPC or B-OPC (p < 0.05). Furthermore, the glycol...

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