期刊论文

Cardioprotection effect on myocardial ischemia reperfusion injury of L-Carnitine in patients undergoing percutaneous coronary intervention

中文

中国当代医药

1674-4721

2018

25

8

13-16+20

10.3969/j.issn.1674-4721.2018.08.005

湖北省自然科学基金项目（2015CFC843）；

本校为第一机构

目的 探讨左卡尼汀对冠心病PCI术患者心肌缺血再灌注损伤的保护作用.方法 选取我院2014年4月～2016年12月符合标准拟行PCI治疗的60例冠心病患者,按随机数字表法分为治疗组和对照组,各30例.对照组行PCI治疗并口服拜阿司匹林片(100 mg,1次/d)、氯吡格雷片(75 mg,1次/d)、阿托伐他汀钙片(20 mg,每晚口服)、美托洛尔缓释片(23.75～47.50 mg,1次/d)、单硝酸异山梨醇酯缓释片(40 mg,2次/d).治疗组在对照组治疗基础上术前加用左卡尼汀2.0 g静脉滴注,术后1次/d,连续7d.检测两组术前及术后的肌酸激酶同工酶(CK-MB)、肌钙蛋白I(cTnI)、C反应蛋白(CRP)、脑钠肽(BNP)、血浆游离脂肪酸含量(FFA)和左室射血分数...

Objective To investigate cardioprotection effect on myocardial ischemia reperfusion injury of L-Carnitine(L-C)in patients with coronary heart disease(CHD)undergoing percutaneous coronary intervention(PCI).Methods Sixty patients with CHD undergoing PCI from April 2014 to December 2016 in our hospital were selected and divided into the treatment group and the control group through a random number table method,30 cases in each group.The control group was treated with PCI and oral Aspirin(100 mg,1 time/d),Clopidogrel(75 mg,1 time/d),Atorvastatin Calcium Tablet(20 mg,every night),Metoprolol Zyban(2...