NationalNatural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31271855, 81,402,669]; Hubei Provincial Central Committee Guides Local Science and Technology Development Project [2019ZYYD032]
机构署名：
本校为第一且通讯机构
院系归属：
生命科学与技术学院
摘要：
Excessive consumption of saturated fat leads to non-alcoholic fatty liver disease (NAFLD), which is attenuated by supplementation of n-3 polyunsaturated fatty acids (PUFAs). Endoplasmic reticulum (ER) stress is crucial in the development of NAFLD, but how high-saturated fat diet (HFD) causes ER stress and NAFLD remains unclear. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is involved in hepatic ER stress. We aimed to explore the roles of LOX-1 in HFDinduced ER stress. Male Sprague-Dawley rats were fed an HFD without or with supplementation of fish oil for 16 weeks. The effec...
