This study was supported by National Natural Science Foundation of China (Grant no. 31271855 and 81,402,669), Hubei Provincial Central Committee Guides Local Science and Technology Development Project (Grant no.2019ZYYD032).
机构署名：
本校为第一且通讯机构
院系归属：
生命科学与技术学院
摘要：
Excessive consumption of saturated fat leads to non-alcoholic fatty liver disease (NAFLD), which is attenuated by supplementation of n-3 polyunsaturated fatty acids (PUFAs). Endoplasmic reticulum (ER) stress is crucial in the development of NAFLD, but how high-saturated fat diet (HFD) causes ER stress and NAFLD remains unclear. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is involved in hepatic ER stress. We aimed to explore the roles of LOX-1 in HFD-induced ER stress. Male Sprague–Dawley rats were fed an HFD without or with...
