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Stereochemical determination of four 10-membered ring resorcylic acid lactones from the desert plant endophytic fungus Chaetosphaeronema hispidulum

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成果类型:
期刊论文
作者:
Zheng, Min;Xu, Zhen-Lu;Yang, Run-Mei;Hu, Shen-Cai*;Ding, Gang*;...
通讯作者:
Hu, Shen-Cai;Ding, Gang;Zhang, Yong-Gang
作者机构:
[Hu, Shen-Cai; Zheng, Min] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.
[Ding, Gang; Yang, Run-Mei; Zheng, Min; Xu, Zhen-Lu] Chinese Acad Med Sci & Peking Union Med Coll, Key Lab Bioact Subst & Resources Utilizat Chinese, Inst Med Plant Dev, Minist Educ, Beijing 100193, Peoples R China.
[Zhang, Yong-Gang; Xu, Zhen-Lu] Qilu Univ Technol, Shandong Acad Sci, Inst Biol, Jinan 250103, Shandong, Peoples R China.
[Zhang, Yong-Gang; Xu, Zhen-Lu] Shandong Normal Univ, Coll Life Sci, Jinan 250014, Shandong, Peoples R China.
[Qin, Jian-Chun] Jilin Univ, Coll Plant Sci, Changchun 130062, Jilin, Peoples R China.
通讯机构:
[Hu, Shen-Cai] W
[Ding, Gang] C
[Zhang, Yong-Gang] Q
[Zhang, Yong-Gang] S
Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.
语种:
英文
关键词:
cytotoxic agent;hispidulactone b;hispidulactone f;lactone derivative;sonnerlactone;unclassified drug;antineoplastic agent;lactone;Article;biosynthesis;carbon nuclear magnetic resonance;cell proliferation;Chaetosphaeronema hispidulum;cytotoxicity;drug determination;electrospray mass spectrometry;endophytic fungus;Hep-G2 cell line;heteronuclear multiple bond correlation;heteronuclear single quantum coherence;high performance liquid chromatography;human;human cell;nonhuman;priority journal;proton nuclear magnetic resonance;stereochemistry;stereoisomerism;X ray diffraction;Ascomycetes;chemistry;endophyte;microbiology;nuclear magnetic resonance spectroscopy;plant;procedures;tumor cell line;Antineoplastic Agents;Ascomycota;Cell Line, Tumor;Endophytes;Hep G2 Cells;Humans;Lactones;Magnetic Resonance Spectroscopy;Plants;Stereoisomerism
期刊:
JOURNAL OF ANTIBIOTICS
ISSN:
0021-8820
年:
2020
卷:
73
期:
7
页码:
471-474
基金类别:
Acknowledgements We acknowledge financial support from the National Key Research and Development Program of China “Research and Development of Comprehensive Technologies on Chemical Fertilizer and Pesticide Reduction and Synergism” (2017YFD0201402 for D. G), National Natural Science Foundation of China (31670011 for YGZ), the Special Project for Academic Construction of Peking Union Medical College (Tsinghua, 211-201920100902 for GD), the National Major Increase or Decrease Project-Construction of the Sustainable Utilization Capacity of Famous Traditional Chinese Medicine Resources (2060302 for JCQ).
机构署名:
本校为第一且通讯机构
院系归属:
生命科学与技术学院
摘要:
Four 10-membered ring resorcylic acid lactones (RALs) including a new compound hispidulactone F (1) and three known analogs hispidulactone B (2), 2 R, 4R-sonnerlactone (3), and 2 R, 4S-sonnerlactone (4) were isolated from the special bioenvironmental desert plant endophytic fungus Chaetosphaeronema hispidulum. The structure of the new compound hispidulactone F (1) was determined by extensive spectra analysis including HR-ESI-MS, NMR (1H, 13C, 1H-1H COSY, HSQC, and HMBC). Hispidulactone F (1) and hispidulactone B (2) were a pair of stereoisomers...

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