BACKGROUND: Liquid-liquid phase separation has been reported to be closely related to the development and occurrence of tumors, but its role in osteosarcoma remains unexplored. METHODS: For the first time, based on liquid-liquid phase separation related genes (LLPSRGs), a prognostic model was constructed through multivariate Cox regression. The model was validated on an independent dataset. The patients were grouped based on the median risk score. Simultaneously conduct immune infiltration analysis, enrichment analysis and drug sensitivity evaluation. RESULTS: We have identified for the first ...