Immunological characterization and prognostic of colon cancer evaluated by angiogenesis-related features: a computational analysis and in vitro experiments

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Fei;Wang, Yi;Xia, Leiming;Sun, Chen;Li, Yun;...

通讯作者：

Xia, YH

作者机构：

[Sun, Chen; Liu, Fei; Xia, Yunhong; Xia, YH] Anhui Med Univ, Affiliated Hosp 1, Dept Oncol, Hefei, Peoples R China.

[Sun, Chen; Liu, Fei; Xia, Yunhong; Xia, YH] Anhui Publ Hlth Clin Ctr, Dept Oncol, Hefei, Anhui, Peoples R China.

[Wang, Yi] Anhui Med Univ, Affiliated Hosp 3, Dept Oncol, Anhui, Peoples R China.

[Xia, Leiming] Anhui Med Univ, Affiliated Hosp 1, Dept Hematol, Hefei, Peoples R China.

[Xia, Leiming] Anhui Publ Hlth Clin Ctr, Dept Hematol, Hefei 230011, Peoples R China.

通讯机构：

[Xia, YH ] A

Anhui Med Univ, Affiliated Hosp 1, Dept Oncol, Hefei, Peoples R China.

Anhui Publ Hlth Clin Ctr, Dept Oncol, Hefei, Anhui, Peoples R China.

语种：

英文

关键词：

Colon cancer;Angiogenesis;TNFRSF1B;Prognosis;Immune

期刊：

Discover Oncology

ISSN：

2730-6011

年：

2025

卷：

期：

页码：

1-13

DOI：

10.1007/s12672-025-01835-6

基金类别：

Not applicable.

机构署名：

本校为其他机构

院系归属：

生命科学与技术学院

摘要：

BACKGROUND: Diseases are often caused by multiple factors, angiogenesis-related genes (ARGs) have been shown to be associated with cancer, however, their role in colon cancer had not been fully explored. This study investigated potential biomarkers based on ARGs to improve prognosis and treatment effect in colon cancer. METHODS: ARGs associated with colon cancer prognosis were identified using Cox regression analysis and LASSO analysis. Furthermore, a prognostic model was constructed in colon cancer based on the 3 ARGs, and its biological function were analyzed. We evaluated the differences in...

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Immunological characterization and prognostic of colon cancer evaluated by angiogenesis-related features: a computational analysis and in vitro experiments

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