LAMTOR1/mTORC1 promotes CD276 to induce immunosuppression via PI3K/ Akt/MMP signaling pathway in Clostridium perfringens-induced necrotic enteritis of laying hens

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成果类型：

期刊论文

作者：

Dong, Qiaoli;Sun, Yamin;Li, Jingyang;Tian, Xinyue;Liu, Siyu;...

通讯作者：

Fu, SL

作者机构：

[Dong, Qiaoli; Luo, Ronghui; Fu, Yunjian; Ye, Chun; Qiu, Yinsheng; Lu, Qirong; Sun, Yamin; Fu, Shulin; Tian, Xinyue; Liu, Siyu; Zong, Bingbing; Li, Jingyang; Guo, Ling] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

[Dong, Qiaoli; Luo, Ronghui; Fu, Yunjian; Ye, Chun; Lu, Qirong; Sun, Yamin; Fu, Shulin; Tian, Xinyue; Liu, Siyu; Zong, Bingbing; Li, Jingyang; Guo, Ling] Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Safe, Wuhan 430023, Peoples R China.

通讯机构：

[Fu, SL ] W

Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Safe, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

CD276;Clostridium perfringens;PI3K/Akt/MMP;immunosuppression;necrotic enteritis

期刊：

Poultry Science

ISSN：

0032-5791

年：

2024

卷：

103

期：

页码：

104216

DOI：

10.1016/j.psj.2024.104216

基金类别：

Key Research and Development Plan of Hubei Province, China [2023BBB069]

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Clostridium perfringens (C. perfringens) causes avian necrotic enteritis, leading to huge economic losses to the poultry industry. This pathogen induces host immunosuppression; however, the molecular mechanism is still unclear. Thus, we established a laying hen infection model to explore this mechanism. We randomly divided 20 one-old-day laying hens into the control and infection groups. The infection group was infected intragastrically with 1 × 10(9) colony-forming units of C. perfringens in 1 mL of sterile phosphate-buffered saline (PBS) onc...

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LAMTOR1/mTORC1 promotes CD276 to induce immunosuppression via PI3K/ Akt/MMP signaling pathway in Clostridium perfringens-induced necrotic enteritis of laying hens

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