期刊论文

Liu, Z.

英文

Food & Nutrition Research

1654-6628

2022

66

10.29219/fnr.v66.7653

This study was supported by the National Natural Science Foundation of China (Grant No. 31271855), the Thirteen-Fifth Mega-Scientific Project (Grant No. 2017ZX10201301-003-003), Wuhan Science and Technology Project (Grant No. 2018020402011230), and the central government guides local science and technology development projects (Grant No. 2019ZYYD).

本校为第一机构

Background: Disturbance of circadian rhythm leads to abnormalities in bile acid (BA) and lipid metabolism, and it is of great significance to explore the relationship between them. This study explored the effects of circadian dysregulation on the rhythms of intestinal BA metabolism. Method: Period circadian clock 1/period circadian clock 2 (Per1/Per2) double gene knockout (DKO) and wild-type (WT) male C57BL/6 mice were fed with a control or high-fat diet for 16 weeks. We measure plasma parameters of mice. Pathological changes including those in...