This research was supported by grants from the National Key R&D Program of China (2022YFD1300403), the National Natural Science Foundation of China (No. U22A20517) and the Science and Technology Research Program of Hubei Provincial Department of Education (No. D20221603).
机构署名：
本校为第一机构
院系归属：
动物科学与营养工程学院
摘要：
We assessed differentially expressed (DE) mRNAs and lncRNAs in the liver of septic pigs to explore the key factors regulating lipopolysaccharide (LPS)-induced liver injury. We identified 543 DE lncRNAs and 3642 DE mRNAs responsive to LPS. Functional enrichment analysis revealed the DE mRNAs were involved in liver metabolism and other pathways related to inflammation and apoptosis. We also found significantly upregulated endoplasmic reticulum stress (ERS)-associated genes, including the receptor protein kinase receptor-like endoplasmic reticulum...
