期刊论文

英文

Frontiers in Immunology

1664-3224

2022

13

10.3389/fimmu.2022.1007202

Technology Innovation Research Team in the University of Sichuan Province; Sichuan Agricultural University Double Branch Program; [KM406183.1]; [03571146]

本校为其他机构

The oral mucosal vaccine has great potential in preventing a series of diseases caused by porcine circovirus type 2 (PCV2) infection. This study constructed a recombinant Bacillus subtilis RB with PCV2 Capsid protein (Cap) on its spore surface and cotB as a fusion partner. The immune properties of the recombinant strain were evaluated in a mouse model. IgA in intestinal contents and IgG in serum were detected by enzyme-linked immunosorbent assay (ELISA). The results demonstrated that recombinant spores could activate strong specific mucosal and humoral immune responses. In addition, spores sho...