A combination of puerarin and poria cococs polysaccharide alleviates the excessive autophagy-caused jejunal injury by increasing serine dehydratase like (SDSL) levels in PEDV-infected piglets
National Natural Science Foundation of China [U22A20514, 32172763]; National Key R&D Program of China [2022YFD130040302]; Hubei Provincial Key RD Program [2023BBB040]; Research and Innovation Initiatives of WHPU [2024J04]
机构署名：
本校为第一且通讯机构
院系归属：
动物科学与营养工程学院
摘要：
This study aims to elucidate the mechanism underlying the reduced jejunal injury in PEDV-challenged piglets after oral administration of puerarin and poria cocos polysaccharides combination (PR + PCP, PP). Results showed that the PEDV challenge caused damage to the small intestine by injuring the villi and inducing redox imbalance which exacerbated the diarrhea of piglets, while PP administration trended to reduce the PEDV infection-caused diarrhea in piglets by alleviating the jejunal injury and restoring the redox balance. Further proteomics and qPCR results showed that PP could significantl...
