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Network pharmacology screening, in vitro and in vivo evaluation of antianxiety and antidepressant drug-food analogue

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成果类型:
期刊论文
作者:
Luo, Ting;Zhao, Zhi-heng;Wu, Min-rui;Ren, Xiao-yu;Xu, Zi-yang;...
通讯作者:
Wang, LM
作者机构:
[Wang, Hong-xun; Luo, Ting; Wang, Li-mei; Xu, Zi-yang; Wu, Min-rui; Zhao, Zhi-heng; Li, Long-jie; Ren, Xiao-yu] Wuhan Polytech Univ, Coll Life Sci & Technol, Wuhan 430023, Peoples R China.
[Yi, Yang] Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Peoples R China.
通讯机构:
[Wang, LM ] W
Wuhan Polytech Univ, Coll Life Sci & Technol, Wuhan 430023, Peoples R China.
语种:
英文
关键词:
Anxiety;Depression;Molecular docking;Network pharmacology
期刊:
Phytomedicine
ISSN:
0944-7113
年:
2024
卷:
134
页码:
155999
基金类别:
Hubei Province Natural Science Foundation of China [2022CFB429]; Wuhan East Lake New Technology Development Zone "unveiled the list of marshal" [2024KJB351]
机构署名:
本校为第一且通讯机构
院系归属:
食品科学与工程学院
生命科学与技术学院
摘要:
BACKGROUND: Depression and anxiety disorders are prevalent psychiatric conditions, and currently utilized chemical drugs typically come with significant adverse effects. China boasts a wealth of medicinal and food herbs known for their safe and effective properties. PURPOSE: This study aimed to develop novel formulations with improved antidepressant and anxiolytic effects derived from medicinal and food herbs. STUDY DESIGN: Screening combinations with antidepressant and anxiolytic effects using techniques such as network pharmacology and validating their effects in vitro and in vivo experiment...

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