Activation of Pyruvate Dehydrogenase by Sodium Dichloroacetate Shifts Metabolic Consumption from Amino Acids to Glucose in IPEC-J2 Cells and Intestinal Bacteria in Pigs

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成果类型：

期刊论文

作者：

Rui An;Tang, Zhiru;Li, Yunxia;Li, Tiejun;Xu, Qingqing;...

通讯作者：

Sun, Zhihong;Yin, Yulong;Jiang Qingyan;Zhu, Weiyun

作者机构：

[Sun, Jiajing; Zhen, Jifu; Wu, Zhaoliang; Rui An; Jing Yang; Wu, Liuting; Sun, Zhihong; Mao Li; Tang, Zhiru; Xu, Qingqing; Zhang, Xiangxin; Cheng Chen; Chen, Jinchao] Southwest Univ, Coll Anim Sci & Technol, Lab Biofeed & Mol Nutr, Chongqing 400715, Peoples R China.

[Li, Yunxia] Sichuan Agr Univ, Inst Anim Nutr, Chengdu 611130, Sichuan, Peoples R China.

[Li, Tiejun; Yin, Yulong] Chinese Acad Sci, Inst Subtrop Agr, Changsha 410125, Hunan, Peoples R China.

[Huang, Feiru] Huazhong Agr Univ, Coll Anim Sci & Technol, Wuhan 430070, Hubei, Peoples R China.

[Zhao, Shengjun] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Wuhan 430023, Hubei, Peoples R China.

通讯机构：

[Sun, Zhihong] S

[Yin, Yulong] C

[Jiang Qingyan] H

[Zhu, Weiyun] N

Southwest Univ, Coll Anim Sci & Technol, Lab Biofeed & Mol Nutr, Chongqing 400715, Peoples R China.

语种：

英文

关键词：

glucose;glutamate;pyruvate dehydrogenase;sodium dichloroacetate;oxidative metabolism

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2018

卷：

期：

页码：

3793-3800

DOI：

10.1021/acs.jafc.7b05800

基金类别：

National Science and Technology Major Project of China [2017YFD0500504]; National "948" Project from the Ministry of Agriculture of China [2015Z74]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31772610]

机构署名：

本校为其他机构

院系归属：

动物科学与营养工程学院

摘要：

The extensive metabolism of amino acids (AA) as fuel is an important reason for the low use efficiency of protein in pigs. In this study, we investigated whether regulation of the pyruvate dehydrogenase kinase (PDK)/pyruvate dehydrogenase alpha 1 (PDHA1) pathway affected AA consumption by porcine intestinal epithelial (IPEC-J2) cells and intestinal bacteria in pigs. The effects of knockdown of PDHA1 and PDK1 with small interfering RNA (siRNA) on nutrient consumption by IPEC-J2 cells were evaluated. IPEC-J2 cells were then cultured with sodium dichloroacetate (DCA) to quantify AA and glucose co...

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Activation of Pyruvate Dehydrogenase by Sodium Dichloroacetate Shifts Metabolic Consumption from Amino Acids to Glucose in IPEC-J2 Cells and Intestinal Bacteria in Pigs

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