Label-free mass spectrometry-based plasma proteomics identified ly6d, dsc3, cdsn, serpinb12, and slurp1 as novel protein biomarkers for pulmonary tuberculosis

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成果类型：

期刊论文

作者：

Zhang, Lu;Wang, Hualin;Li, Na;Hu, Peng;Zhu, Zhaoqin;...

通讯作者：

Zhang, S.;Yu, X.

作者机构：

[Wang, Hualin; Zhang, Lu; Hu, Peng; Yu, Xiaoli; Li, Na] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan, Peoples R China.

[Zhang, Lu; Song, Yanzheng; Wen, Zilu; Zhu, Zhaoqin; Zhang, Shulin] Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China.

[Wang, Wei] Henan Prov Chest Hosp, Zhengzhou, Peoples R China.

[Zhang, Shulin] Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China.

通讯机构：

[Yu, X.; Zhang, S.] S

Shanghai Jiaotong University School of MedicineChina

School of Biological and Pharmaceutical Engineering, China

Shanghai Public Health Clinical CenterChina

语种：

英文

关键词：

Tuberculosis;plasma;label-free LC-MS/MS;biomarkers;diagnose;proteomics.

期刊：

CURRENT PROTEOMICS

ISSN：

1570-1646

年：

2021

卷：

期：

页码：

50-61

DOI：

10.2174/1570164617666191210105122

基金类别：

This study was supported by the grant from the National Science and Technology Major Project (No. 2017ZX10201301-003-001, No. 2017ZX10201301-003-003), the National Natural Science Foundation of China (No. 81871613) and Shanghai Jiao Tong University School of Medicine Technology China Transfer Project (No. ZT201917).

机构署名：

本校为第一机构

院系归属：

生命科学与技术学院

摘要：

Aim: We aimed to identify new plasma biomarkers for the diagnosis of Pulmonary Tuberculosis (PTB). Background: Tuberculosis is an ancient infectious disease that remains one of the major global health prob-lems. Until now, effective, convenient, and affordable methods for diagnosis of PTB were still lacking. Objective: This study focused on constructing a label-free LC-MS/MS-based comparative proteomics between six tuberculosis patients and six healthy controls to identify Differentially Expressed Proteins (DEPs) in plasma. Methods: To reduce t...

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Label-free mass spectrometry-based plasma proteomics identified ly6d, dsc3, cdsn, serpinb12, and slurp1 as novel protein biomarkers for pulmonary tuberculosis

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