Asparagine preserves intestinal barrier function from LPS-induced injury and regulates CRF/CRFR signaling pathway

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成果类型：

期刊论文

作者：

Zhu, Huiling;Pi, Dingan;Leng, Weibo;Wang, Xiuying;Hu, Chien-An Andy;...

通讯作者：

Liu, Yulan

作者机构：

[Hu, Chien-An Andy; Qin, Qin; Liu, Yulan; Leng, Weibo; Xiong, Jianglin; Hou, Yongqing; Wang, Chunwei; Pi, Dingan; Wang, Xiuying; Zhu, Huiling] Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.

[Hu, Chien-An Andy] Univ New Mexico, Sch Med, Dept Biochem & Mol Biol, Albuquerque, NM 87131 USA.

[Liu, Yulan] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Collaborat Innovat Ctr Anim Nutr & Feed Safety, Wuhan 430023, Hubei, Peoples R China.

通讯机构：

[Liu, Yulan] W

Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.

Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Collaborat Innovat Ctr Anim Nutr & Feed Safety, Wuhan 430023, Hubei, Peoples R China.

语种：

英文

关键词：

*Asparagine;*CRF/CRFR1 signaling pathway;*intestinal barrier function;*lipopolysaccharide;*weaned pigs

期刊：

INNATE IMMUNITY

ISSN：

1753-4259

年：

2017

卷：

期：

页码：

546-556

DOI：

10.1177/1753425917721631

基金类别：

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was financially supported by the National Natural Science Foundation of China (31372318 and 31422053) and the State’s Key Project of Research and Development (2016YFD0501210).

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Stress causes intestinal inflammation and barrier dysfunction. Corticotrophin-releasing factor (CRF)/CRF receptor (CRFR) signaling pathway has been shown to be important for stress-induced intestinal mucosal alteration. L-Asparagine (ASN) is a powerful stimulator of ornithine decarboxylase and cell proliferation in a variety of cell types, including colonic cells. In the present study, we investigated whether dietary ASN supplementation could alleviate the damage of intestinal barrier function caused by LPS through modulation of CRF/CRFR signaling pathway. Twenty-four weaned pigs were randomly...

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Asparagine preserves intestinal barrier function from LPS-induced injury and regulates CRF/CRFR signaling pathway

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