期刊论文

Zhang, JQ

英文

Nutrients

2072-6643

2025

17

13

2086-

10.3390/nu17132086

This study was supported by National Key R&D Program of China (2024YFD1300405), Hubei Province Key Laboratory of Animal Nutrition and Feed Science (202409), the Research and Innovation Initiatives of WHPU (202410496046), the Research and Innovation Initiatives of WHPU (2024Y22; 2025RZ026).

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Background: The limited bioavailability of free phytosterols restricts their clinical application in managing hypercholesterolemia. This study aimed to develop phytosterol nanoparticles (PNs) to enhance bioactivity and investigate their cholesterol-lowering efficacy and underlying mechanisms in vivo. Methods: Phytosterol nanoparticles (PNs) (93.35 nm) were engineered using soy protein isolate and administered orally at concentrations of 4.00-12.50 mg/mL to high-fat-diet-induced hypercholesterolemic mice (n = 60) over a 4-week period. Serum and hepatic lipid profiles, histopathology, gene/prote...