Human telomere sequences (TTAGGG)(n) fold into G-quadruplexes with different conformations in K(+) and Na(+) solutions, which are highlighted for their potential as antitumor drug targets. Moreover, human multimeric G-quadruplexes have been broadly studied potentially for screening ligands with higher selectivity than monomeric G-quadruplexes. Most insects have telomeres consisting of pentanucleotide (TTAGG) repeats, which fold into an antiparallel structured G-quadruplex with a two-layer G-planar in a K(+) solution. However, the structure of insect telomeric G-quadruplexes in Na(+) solutions ...
