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In utero exposure to per- and polyfluoroalkyl substances and neonatal sex hormone levels: Implications of endocrine disrupting effects during critical development windows

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成果类型:
期刊论文
作者:
Xia, Zhunan;Chen, Shiyi;Liu, Youren;Li, Jingguang;Liu, Xin;...
通讯作者:
Liu, X;Zhang, L;Xiang, Q
作者机构:
[Xia, Zhunan; Chen, Shiyi; Liu, Xin] Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education, College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China
[Liu, Youren] Chengdu Institute of Food Inspection, Irradiation Preservation Key Laboratory of Sichuan Province, Chengdu 611130, China
[Li, Jingguang; Zhang, Lei] NHC Key Lab of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing 100010, China
[Xiang, Qian] Healthcare-associated Infection Control Center, Sichuan Academy of Medical Sciences, Sichuan People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China
[Wu, Yongning] Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education, College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China<&wdkj&>NHC Key Lab of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing 100010, China
通讯机构:
[Xin Liu] K
[Qian Xiang] H
Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education, College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China<&wdkj&>Healthcare-associated Infection Control Center, Sichuan Academy of Medical Sciences, Sichuan People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China
语种:
英文
关键词:
PFASs;Prenatal exposure;Neonatal sex hormone;Bayesian benchmark dose;Toxicogenomics
期刊:
Environmental Chemistry and Ecotoxicology
ISSN:
2590-1826
年:
2025
卷:
7
页码:
1587-1597
基金类别:
National Key Research and Develpment Program of China [2022YFF1102500]; National Natural Science Foundation of Chinna [21976046]
机构署名:
本校为第一且通讯机构
院系归属:
食品科学与工程学院
摘要:
Emerging evidence indicates that prenatal exposure to per - and polyfluoroalkyl substances (PFASs) may adversely affect endocrine function, particularly during critical windows of fetal development. This study evaluated the impact of prenatal PFAS exposure on neonatal sex hormone levels—total testosterone, estradiol, prolactin, and progesterone—in a cohort of newborns from Beijing, China. We quantified 19 individual PFAS compounds and examined their individual and combined effects on neonatal hormone levels using linear regression, restricted...

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