Protective effects of 18β-glycyrrhetinic acid on Pasteurella multocida-induced vascular inflammatory injury in mice

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成果类型：

期刊论文

作者：

Lu, Qirong;Wang, Luyao;Jiang, Xueping;Han, Wantong;Guo, Pu;...

通讯作者：

Liu, Yu;Qiu, YS

作者机构：

[Liu, Yu; Han, Wantong; Xiong, Jianglin; Qiu, Yinsheng; Wang, Luyao; Guo, Pu; Jiang, Xueping; Wu, Zhongyuan; Fu, Shulin; Lu, Qirong] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan, Peoples R China.

[Liu, Yu; Han, Wantong; Xiong, Jianglin; Qiu, Yinsheng; Wang, Luyao; Guo, Pu; Jiang, Xueping; Wu, Zhongyuan; Fu, Shulin; Lu, Qirong] Wuhan Polytech Univ, Wuhan Engn & Technol Res Ctr Anim Dis Resistant Nu, Sch Anim Sci & Nutr Engn, Wuhan, Peoples R China.

通讯机构：

[Liu, Y; Qiu, YS ] W

Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan, Peoples R China.

Wuhan Polytech Univ, Wuhan Engn & Technol Res Ctr Anim Dis Resistant Nu, Sch Anim Sci & Nutr Engn, Wuhan, Peoples R China.

语种：

英文

关键词：

18 beta-glycyrrhetinic acid;inflammatory response;Pasteurella multocida;protective effects;vascular injury

期刊：

Frontiers in Veterinary Science

ISSN：

2297-1769

年：

2025

卷：

页码：

1515977

DOI：

10.3389/fvets.2024.1515977

基金类别：

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was funded by National Natural Science Foundation of China (NSFC) (32202867), Key Research and Development Plan of Hubei Province, China (2023BBB069) and the Open Project of Hubei Key Laboratory of Animal Nutrition and Feed Science (202404).

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Pasteurella multocida (Pm) is a widespread zoonotic pathogen with the ability to infect wild animals, livestock, and humans. Pm infection can cause haemorrhagic pneumonia, indicating that the pathogenesis involves serious vascular injury and inflammation. 18β-Glycyrrhetinic acid (GA) has cardiovascular protective and anti-inflammatory effects, but its effect on vascular injury caused by Pm infection is not clear. This study focused on the protective effects of GA on Pm-induced vascular inflammatory injury in mice. The results showed that GA in...

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Protective effects of 18β-glycyrrhetinic acid on Pasteurella multocida-induced vascular inflammatory injury in mice

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