Effects of Molecular Crowding on the Structure, Stability, and Interaction with Ligands of G-quadruplexes

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成果类型：

期刊论文

作者：

Gao, Chao;Mohamed, Hany I.;Deng, Jieya;Umer, Muhammad;Anwar, Naureen;...

通讯作者：

Chao Gao<&wdkj&>Yi He

作者机构：

[He, Yi; Wang, Zhangqian; Gao, Chao; Deng, Jieya; Chen, Jixin] Wuhan Polytech Univ, Sch Modern Ind Selenium Sci & Engn, Natl R&D Ctr Se Rich Agr Prod Proc, Hubei Engn Res Ctr Deep Proc Green Se Rich Agr Pro, Wuhan 430023, Peoples R China.

[Mohamed, Hany I.] Benha Univ, Fac Sci, Chem Dept, Banha 13518, Egypt.

[Umer, Muhammad] Guizhou Univ, Inst Forest Resources & Environm Guizhou, Guiyang 550025, Peoples R China.

[Umer, Muhammad] Guizhou Univ, Forestry Coll, Res Ctr Forest Ecol, Guiyang 550025, Peoples R China.

[Anwar, Naureen] Univ Narowal, Dept Zool, Narowal 51600, Punjab, Pakistan.

通讯机构：

[Chao Gao; Yi He] N

National R&D Center for Se-rich Agricultural Products Processing, Hubei Engineering Research Center for Deep Processing of Green Se-rich Agricultural Products, School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China

语种：

英文

期刊：

ACS OMEGA

ISSN：

2470-1343

年：

2023

卷：

期：

页码：

14342-14348

DOI：

10.1021/acsomega.3c01169

基金类别：

National Natural Science Foundation of China [31900011]; Ganzhou General Inspection and Testing Institute [GZSZJYKF-202209]; Enshi Se-Run Material Engineering Technology Co., Ltd. [Sel202104]; Research and Innovation Initiatives of WHPU; Technical Reserve Project from School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University

机构署名：

本校为第一机构

院系归属：

硒科学与工程现代产业学院

摘要：

G-quadruplexes (G4s) are widely found in cells and have significant biological functions, which makes them a target for screening antitumor and antiviral drugs. Most of the previous research on G4s has been conducted mainly in diluted solutions. However, cells are filled with organelles and many biomolecules, resulting in a constant state of a crowded molecular environment. The conformation and stability of some G4s were found to change significantly in the molecularly crowded environment, and interactions with ligands were disturbed to some extent. The structure of the G4s and their biologica...

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Effects of Molecular Crowding on the Structure, Stability, and Interaction with Ligands of G-quadruplexes

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