Chlorine disinfection byproduct of diazepam affects nervous system function and possesses gender-related difference in zebrafish

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成果类型：

期刊论文

作者：

Zhao, Xiaole;Huang, Xiaoyong;Peng, Wenjing;Zhang, Xin;Zhu, Kui;...

通讯作者：

Kui Zhu

作者机构：

[Huang, Xiaoyong; Zhu, Kui; Shao, Bing; Zhao, Xiaole; Peng, Wenjing] China Agr Univ, Coll Vet Med, 2 Yuanmingyuan West Rd, Beijing 100193, Peoples R China.

[Zhao, Xiaole] Wuhan Polytech Univ, Inst Food Sci & Engn, Wuhan 430023, Peoples R China.

[Huang, Xiaoyong; Zhang, Xin; Shao, Bing] Beijing Ctr Dis Prevent & Control, Beijing Key Lab Diagnost & Traceabil Technol Food, Beijing 100013, Peoples R China.

[Zhu, Kui] 2 Yuanmingyuan West Rd, Beijing 100193, Peoples R China.

[Shao, Bing] 16 Hepingli Middle St, Beijing 100013, Peoples R China.

通讯机构：

[Kui Zhu] C

College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Beijing 100193, People’s Republic of China

语种：

英文

关键词：

2-methylamino-5-chlorobenzophenone;CYP1A2;Gender-related difference;Zebrafish

期刊：

Ecotoxicology and Environmental Safety

ISSN：

0147-6513

年：

2022

卷：

238

页码：

113568

DOI：

10.1016/j.ecoenv.2022.113568

基金类别：

This study was supported by the National Natural Science Foundation of China ( 21677019 ) and Capital Foundation of Medicine Research and Development ( 2018–1–302 ).

机构署名：

本校为其他机构

院系归属：

食品科学与工程学院

摘要：

Chlorinated disinfection byproducts in water posed potential health threat to humans. Nowadays, chlorinated derivatives of diazepam were ubiquitously detected in drinking water. Among these derivatives, 2-methylamino-5-chlorobenzophenone (MACB) was capable of penetrating the blood-brain barrier (BBB) and induced microglial phagocytosis of neurons in zebrafish. However, little is known about the MACB metabolism in vivo. Here, we determined the metabolism of MACB in zebrafish and microglia cell model. We found that MACB mainly disrupted the metab...

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Chlorine disinfection byproduct of diazepam affects nervous system function and possesses gender-related difference in zebrafish

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