Nicotinamide mononucleotide alleviates seizures via modulating SIRT1-PGC-1α mediated mitochondrial fusion and fission

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Cheng, Yahong;Huang, Puxin;Zou, Qixian;Tian, Hui;Cheng, Qingzhou;...

通讯作者：

Cheng, YH;Ding, H

作者机构：

[Cheng, Qingzhou; Tian, Hui; Cheng, Yahong] Wuhan Polytech Univ, Coll Med & Hlth Sci, Wuhan, Hubei, Peoples R China.

[Zou, Qixian; Ding, Hong; Huang, Puxin] Wuhan Univ, Sch Pharmaceut Sci, Wuhan, Hubei, Peoples R China.

[Cheng, Yahong] Wuhan Polytech Univ, Coll Med & Hlth Sci, 68 Xuefu South Rd, Wuhan 430023, Hubei, Peoples R China.

[Ding, Hong; Ding, H] Wuhan Univ, Sch Pharmaceut Sci, 185 Donghu Rd, Wuhan 430072, Hubei, Peoples R China.

通讯机构：

[Ding, H ; Cheng, YH ] W

Wuhan Polytech Univ, Coll Med & Hlth Sci, 68 Xuefu South Rd, Wuhan 430023, Hubei, Peoples R China.

Wuhan Univ, Sch Pharmaceut Sci, 185 Donghu Rd, Wuhan 430072, Hubei, Peoples R China.

语种：

英文

关键词：

SIRT1/PGC‐1α pathway;epilepsy;mitochondrial fission;mitochondrial fusion;nicotinamide mononucleotide

期刊：

Journal of Neurochemistry

ISSN：

0022-3042

年：

2024

卷：

168

期：

页码：

3962-3981

DOI：

10.1111/jnc.16041

基金类别：

This study was supported by the National Natural Science Foundation of China (NSFC; Grant No. 82301650). This study was supported by the National Natural Science Foundation of China with grant No. 82301650. And we would like to thank Professor Qi Li for his help in the research design and manuscript modification.

机构署名：

本校为第一且通讯机构

院系归属：

医学与健康学院

摘要：

Both human and animal experiments have demonstrated that energy metabolism dysfunction in neurons after seizures is associated with an imbalance in mitochondrial fusion/fission dynamics. Effective neuronal mitochondrial dynamics regulation strategies remain elusive. Nicotinamide mononucleotide (NMN) can ameliorate mitochondrial functional and oxidative stress in age-related diseases. But whether NMN improves mitochondrial energy metabolism to exert anti-epileptic effects is unclear. This study aims to clarify if NMN can protect neurons from pen...

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Nicotinamide mononucleotide alleviates seizures via modulating SIRT1-PGC-1α mediated mitochondrial fusion and fission

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