Nicotinamide mononucleotide alleviates seizures via modulating SIRT1‐PGC‐1α mediated mitochondrial fusion and fission

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Cheng, Yahong;Huang, Puxin;Zou, Qixian;Tian, Hui;Cheng, Qingzhou;...

通讯作者：

Cheng, YH;Ding, H

作者机构：

[Cheng, Qingzhou; Tian, Hui; Cheng, Yahong] Wuhan Polytech Univ, Coll Med & Hlth Sci, Wuhan, Hubei, Peoples R China.

[Zou, Qixian; Ding, Hong; Huang, Puxin] Wuhan Univ, Sch Pharmaceut Sci, Wuhan, Hubei, Peoples R China.

[Cheng, Yahong] Wuhan Polytech Univ, Coll Med & Hlth Sci, 68 Xuefu South Rd, Wuhan 430023, Hubei, Peoples R China.

[Ding, Hong; Ding, H] Wuhan Univ, Sch Pharmaceut Sci, 185 Donghu Rd, Wuhan 430072, Hubei, Peoples R China.

通讯机构：

[Ding, H ; Cheng, YH ] W

Wuhan Polytech Univ, Coll Med & Hlth Sci, 68 Xuefu South Rd, Wuhan 430023, Hubei, Peoples R China.

Wuhan Univ, Sch Pharmaceut Sci, 185 Donghu Rd, Wuhan 430072, Hubei, Peoples R China.

语种：

英文

关键词：

SIRT1/PGC-1α pathway;epilepsy;mitochondrial fission;mitochondrial fusion;nicotinamide mononucleotide

期刊：

Journal of Neurochemistry

ISSN：

0022-3042

年：

2024

页码：

DOI：

10.1111/jnc.16041

基金类别：

National Natural Science Foundation of China; [82301650]

机构署名：

本校为第一且通讯机构

院系归属：

医学与健康学院

摘要：

Nicotinamide mononucleotide (NMN) could reduce seizure intensity and improve cognitive function in epileptic animals. Additionally, NMN exhibited inhibitory effects on neuronal apoptosis. These therapeutic effects were found associated with the down‐regulation of fission proteins (Drp1 and Fis1) and the up‐regulation of fusion proteins (Mfn1 and Mfn2) through the SIRT1‐PGC‐1α pathway, thus promoting mitochondrial energy metabolism protection. These findings suggest that NMN intervention may serve as a novel potential therapeutic approach f...

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Nicotinamide mononucleotide alleviates seizures via modulating SIRT1‐PGC‐1α mediated mitochondrial fusion and fission

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