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Higher Selective Targeting of Telomeric Multimeric G-quadruplex by Natural Product Berberine

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成果类型:
期刊论文
作者:
Jixin Chen;Yi He;Yang Xu;Muhammad Umer;Naureen Anwar;...
作者机构:
[Wenbin Liu] College of Medicine and Health Science, Wuhan Polytechnic University, Wuhan, 430023, China
[Muhammad Umer] Research Center of Forest Ecology, Institute for Forest Resources and Environment of Guizhou and Forestry College, Guizhou University, Guiyang, 550025, China
[Yang Xu] Wuhan Polytechnic University School of Modern Industry for Selenium Science and Engineering Wuhan China
[Jixin Chen; Yi He; Shiya Wei; Zhangqian Wang; Chao Gao] National R&
[Jixin Chen; Yi He; Shiya Wei; Zhangqian Wang; Chao Gao] D Center for Se-rich Agricultural Products Processing, Hubei Engineering Research Center for Deep Processing of Green Se-rich Agricultural Products, School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan, 430023, China
语种:
英文
关键词:
DNA.;Telomeric multimeric G-quadruplexes;UV titrations;berberine;electrophoresis;interaction mechanisms
期刊:
CURRENT MEDICINAL CHEMISTRY
ISSN:
0929-8673
年:
2025
卷:
32
页码:
1-13
机构署名:
本校为第一机构
院系归属:
医学与健康学院
硒科学与工程现代产业学院
摘要:
Introduction: G-quadruplexes (G4s) are non-classical high-level structures that are formed by DNA/RNA sequences and have been a promising target for developing antitumor drugs. However, it is still a challenge to find a ligand that binds to a particular G4 with selectivity. Telomeric multimeric G4s are more accessible for screening for specific ligands due to their higher-order structure compared with telomeric monomeric G4s.Methods : In this study, the natural product berberine was found to exhibit a higher selectivity for telomeric multimeric G4 in comparison with other G4s. The mechanism of...

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