Selenium deficiency-induced high concentration of reactive oxygen species restricts hypertrophic growth of skeletal muscle in juvenile zebrafish by suppressing TORC1-mediated protein synthesis

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成果类型：

期刊论文

作者：

Wang, Li;Yin, Jiaojiao;Liao, Chenlei;Cheng, Rui;Chen, Feifei;...

通讯作者：

Zhang, XZ

作者机构：

[Cheng, Rui; Wang, Li; Zhang, Xuezhen; Liao, Chenlei; Chen, Feifei; Yu, Haodong] Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China.

[Wang, Li] Wuhan Polytech Univ, Natl R&D Ctr Se Rich Agr Prod Proc, Wuhan 430048, Peoples R China.

[Wang, Li] Wuhan Polytech Univ, Sch Modern Ind Selenium Sci & Engn, Wuhan 430048, Peoples R China.

[Yin, Jiaojiao] Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Peoples R China.

[Zhang, Xuezhen] Minist Educ, Engn Res Ctr Green Dev Convent Aquat Biol Ind Yang, Wuhan 430070, Peoples R China.

通讯机构：

[Zhang, XZ ] H

Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China.

Minist Educ, Engn Res Ctr Green Dev Convent Aquat Biol Ind Yang, Wuhan 430070, Peoples R China.

Hubei Prov Engn Lab Pond Aquaculture, Wuhan 430070, Peoples R China.

语种：

英文

关键词：

Selenium;Zebrafish;Skeletal muscle growth;Redox;Protein synthesis

期刊：

British Journal of Nutrition

ISSN：

0007-1145

年：

2023

卷：

130

期：

页码：

1841-1851

DOI：

10.1017/S0007114523000934

基金类别：

National Key Research and Development Program of China [2019YFD0900303]; China Postdoctoral Science Foundation [2021M691171]

机构署名：

本校为其他机构

院系归属：

食品科学与工程学院

硒科学与工程现代产业学院

摘要：

Selenium (Se) deficiency causes impaired growth of fish skeletal muscle due to the retarded hypertrophy of muscle fibers. However, the inner mechanisms remain unclear. According to our previous researches, we infer this phenomenon is associated with Se deficiency-induced high concentration of reactive oxygen species (ROS), which could suppress the target of rapamycin complex 1 (TORC1) pathway-mediated protein synthesis by inhibiting protein kinase B (Akt), an upstream protein of TORC1. To test this hypothesis, juvenile zebrafish (45 days post f...

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Selenium deficiency-induced high concentration of reactive oxygen species restricts hypertrophic growth of skeletal muscle in juvenile zebrafish by suppressing TORC1-mediated protein synthesis

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