Objective: To study the time-effect and dose-effect relationships of reducing uric acid of one complex extraction. Methods: Sixty male Kunming mice were randomly divided into blank group, model group, allopurinol group, and three groups of high, medium, and low complex extraction group. In the study of time-effect relationship, the mice were continuously treated with complex extraction for 2, 4, 7, 10, 13, 16, and 20 d, then the rats model was established by ip administration with oxonic acid potassium salt (20 mL/kg); In the study of dose-effe...