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Integrated chemical and transcriptomic analyses unveils synthetic characteristics of different medicinal root parts of Angelica sinensis

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成果类型:
期刊论文
作者:
Ran Xu;Jiang Xu;Yong-chang Li;Yun-tao Dai;Shao-peng Zhang;...
通讯作者:
Lin-lin Dong<&wdkj&>Shi-lin Chen
作者机构:
College of Biology and Pharmaceutical Engineering,Wuhan Polytechnic University,Wuhan 430000,China
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences, Beijing 100700,China
[Jiang Xu; Yun-tao Dai; Lin-lin Dong; Shi-lin Chen] Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
[Yong-chang Li] Kansas City University of Medicine and Biosciences, Joplin 64804, USA
[Shao-peng Zhang; Guang Wang; Zhi-guo Liu] College of Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430000, China
通讯机构:
[Lin-lin Dong; Shi-lin Chen] I
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
语种:
英文
关键词:
Angelicae Sinensis Radix;biosynthesis;comparative transcriptomics;ferulic acid;three medicinal root parts
期刊:
中草药:英文版
ISSN:
1674-6384
年:
2020
卷:
12
期:
1
页码:
19-28
基金类别:
supported by the grants from National Science Foundation of China (grant number 81903782); Hubei Provincial Department of Education Plan for Science & Technology Project (Q20171705); Scientific Research Project of Wuhan Polytechnic University (2018Y10);
机构署名:
本校为第一机构
院系归属:
生命科学与技术学院
摘要:
OBJECTIVE: Why are different medicinal parts including heads, bodies and tails of Angelicae Sinensis Radix (ASR) distinct in pharmaceutical activities? Here we explored their discrepancy in chemical constituents and transcriptome. METHODS: ASR were separated into three medicinal parts: heads (rootstocks with petiole traces of ASR), bodies (taproots of ASR) and tails (lateral roots of ASR), and chemical and transcriptomic analyses were conducted simultaneously. RESULTS: High performance liquid chromatography (HPLC) fingerprint results showed that five widely used active ingredients (ferulic aci...

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