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Assessment of the Macrophage Scavenger Receptor CD163 in Mediating Glaesserella parasuis Infection of Host Cells

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成果类型:
期刊论文
作者:
Deng, Xiangwei;Li, Shuilian;Zhu, Ying;Yu, Bo;Zhang, Jing;...
通讯作者:
Huanhuan Zhou<&wdkj&>Hongbo Chen
作者机构:
[Zhou, Huanhuan; Chen, Hongbo] Wuhan Polytech Univ, Lab Genet Breeding Reprod & Precis Livestock Farmi, Wuhan 430023, Peoples R China.
Wuhan Polytech Univ, Hubei Prov Ctr Technol Innovat Domest Anim Breedin, Sch Anim Sci & Nutr Engn, Wuhan 430023, Peoples R China.
通讯机构:
[Huanhuan Zhou; Hongbo Chen] A
Authors to whom correspondence should be addressed.
语种:
英文
关键词:
Glaesserella parasuis;CD163;receptor;adhesion;host–pathogen interaction
期刊:
Veterinary Sciences
ISSN:
2306-7381
年:
2023
卷:
10
期:
3
页码:
235-
基金类别:
Conceptualization, H.C. and H.Z.; methodology, X.D., S.L. and Y.Z.; software, X.D. and S.L.; validation, H.Z. and H.C.; formal analysis, B.Y. and J.Z.; investigation, H.C., H.Z., X.D., S.L., Y.Z., Q.F. and Z.L.; resources, H.C. and H.Z.; data curation, X.D. and S.L.; writing—original draft preparation, X.D., S.L. and H.Z.; writing—review and editing, H.C. and B.Y.; visualization, X.D. and J.Z.; supervision, H.C. and H.Z.; project administration, H.C.; funding acquisition, H.C. All authors have read and agreed to the published version of the manuscript. This research was funded by the Frontier Project of Wuhan Applied and Basic Research (grant number: 2019020701011494); the National Natural Science Foundation of China (grant number: 32172712); and the Key R&D Project from the Department of Science and Technology of Hubei Province (grant number: 2020BBB070). The APC was funded by the National Natural Science Foundation of China.
机构署名:
本校为第一机构
院系归属:
动物科学与营养工程学院
摘要:
Simple Summary The macrophage CD163 surface glycoprotein is a member of the scavenger receptor cysteine-rich (SRCR) family class B. It has been identified as the receptor for hemoglobin-haptoglobin (Hb-Hp) complexes and erythroblasts, and it is the key trigger in host-pathogen interactions. Previous studies have implicated porcine CD163 in macrophage activation delay upon infection with virulent G. parasuis strains, while its exact roles in sensing G. parasuis infection have not yet been assessed. Here, we investigated the role of CD163 in mediating the adhesion and immune response of G. paras...

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