Simultaneous determination of iloperidone and its two active metabolites in human plasma by liquid chromatography–tandem mass spectrometry: Application to a pharmacokinetic study

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Jia, Mengmeng;Li, Jie;He, Xiaomeng;Liu, Mingzhou;Zhou, Ying;...

通讯作者：

Li, Weiyong

作者机构：

[Li, Jie; He, Xiaomeng; Li, Weiyong; Jia, Mengmeng; Zhou, Ying] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Inst Clin Pharm, Wuhan 430022, Peoples R China.

[Liu, Mingzhou] Wuhan Polytech Univ, Dept Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.

[Fan, Yue] Hubei Coll Tradit Chinese Med, Wuhan 430065, Peoples R China.

通讯机构：

[Li, Weiyong] H

Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Inst Clin Pharm, Wuhan 430022, Peoples R China.

语种：

英文

关键词：

Iloperidone;LC-MS/MS;Liquid chromatography-tandem mass spectrometry;Liquid-liquid extraction;Multiple-reaction monitoring modes;Pioglitazone hydrochlorides;Simultaneous determinations;Tandem mass spectrometry;Chromatography;High performance liquid chromatography;Mass spectrometry;Metabolites;Pharmacokinetics;Plasma (human);Biomolecules;acetic acid ethyl ester;acetonitrile;ammonium formate;formic acid;iloperidone;pioglitazone;accuracy;adult;article;drug half life;drug stability;drug structure;extraction;flow rate;human;human experiment;liquid;liquid chromatography;male;mass spectrometer;metabolite;normal human;plasma;priority journal;separation technique;tandem mass spectrometry;temperature;validation study;Antipsychotic Agents;Chromatography, Liquid;Humans;Isoxazoles;Liquid-Liquid Extraction;Male;Piperidines;Receptors, Dopamine D2;Sensitivity and Specificity;Serotonin 5-HT2 Receptor Antagonists;Tandem Mass Spectrometry

期刊：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

ISSN：

1570-0232

年：

2013

卷：

928

页码：

52-57

DOI：

10.1016/j.jchromb.2013.03.026

基金类别：

important National Science & Technology Specific Projects in the 12th Five year Plan of china [2011ZX09302-002-01]

机构署名：

本校为其他机构

院系归属：

生命科学与技术学院

摘要：

A selective, sensitive and accurate high-performance liquid chromatographic- tandem mass spectrometry (HPLC-MS/MS) method for simultaneous determination of iloperidone and its two active metabolites, P88 and P95, in human plasma has been first developed and validated. The analytes and internal standard (IS), pioglitazone hydrochloride, were extracted from human plasma via liquid-liquid extraction with ethyl acetate and separated on a CAPCELL PAK C18 MG IIIcolumn (150 mm × 2.0 mm, 5 μm) set at 40. °C. The mobile phase was acetonitrile: 5 mM a...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Simultaneous determination of iloperidone and its two active metabolites in human plasma by liquid chromatography–tandem mass spectrometry: Application to a pharmacokinetic study

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问