Target discovery of inhibitors based on a G-quadruplex structure in the potato virus Y genome

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成果类型：

期刊论文

作者：

Gao, Chao;Xu, Yang;Wang, Tao;Zou, Yihan;Xie, Congbao;...

通讯作者：

He, Y;Luo, DH

作者机构：

[Xu, Yang; He, Yi; Wang, Zhangqian; Gao, Chao; Zou, Yihan] Wuhan Polytech Univ, Natl R&D Ctr Se Rich Agr Prod Proc, Hubei Engn Res Ctr Deep Proc Green Se Rich Agr Pro, Sch Modern Ind Selenium Sci & Engn, Wuhan 430023, Peoples R China.

[Wang, Tao] Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei, Peoples R China.

[Luo, Dehua; Xie, Congbao] Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China.

通讯机构：

[Luo, DH ] H

[He, Y ] W

Wuhan Polytech Univ, Natl R&D Ctr Se Rich Agr Prod Proc, Hubei Engn Res Ctr Deep Proc Green Se Rich Agr Pro, Sch Modern Ind Selenium Sci & Engn, Wuhan 430023, Peoples R China.

Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China.

语种：

英文

关键词：

3′‐untranslated region;G‐quadruplexes;antiviral target;potato virus Y

期刊：

Pest Management Science

ISSN：

1526-498X

年：

2025

DOI：

10.1002/ps.70242

基金类别：

Natural Science Foundation of Hubei Province [2024AFB387, 2025AFB288]; Research and Innovation Initiatives of WHPU [2023Y82]; China Postdoctoral Science Foundation [2024M761080]

机构署名：

本校为第一且通讯机构

院系归属：

硒科学与工程现代产业学院

摘要：

BACKGROUND: Potato virus Y (PVY) exhibits a wide host range and significantly affects crop growth. Development of novel targets is an important way to discover highly active PVY inhibitors with novel structure. G-quadruplex (G4) structures formed by guanine-rich nucleic acid sequences, have emerged as validated therapeutic targets driving the development of novel antiviral and antitumor agents. The untranslated regions is a regulatory region for mRNA expression, and the G4s in this region can regulate gene expression. RESULTS: Ten G4 structures...

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Target discovery of inhibitors based on a G-quadruplex structure in the potato virus Y genome

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