The anti-inflammatory effects of acetaminophen and N-acetylcysteine through suppression of the NLRP3 inflammasome pathway in LPS-challenged piglet mononuclear phagocytes

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成果类型：

期刊论文

作者：

Liu, Yu;Yao, Wenxu;Xu, Jun;Qiu, Yinsheng*;Cao, Fangyuan;...

通讯作者：

Qiu, Yinsheng

作者机构：

[Yang, Sheng; Liu, Yu; Xu, Jun; Hou, Yongqing; Qiu, Yinsheng; Li, Sali; Cao, Fangyuan; Wu, Zhongyuan; Yao, Wenxu; Yang, Hailan] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

[Liu, Yu; Hou, Yongqing; Qiu, Yinsheng; Wu, Zhongyuan] Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Wuhan, Peoples R China.

[Qiu, Yinsheng] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, 68 South Xuefu Rd, Wuhan 430023, Peoples R China.

通讯机构：

[Qiu, Yinsheng] W

Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, 68 South Xuefu Rd, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

Acetaminophen;N-acetylcysteine;anti-inflammation;NLRP3 inflammasome;caspase-1

期刊：

INNATE IMMUNITY

ISSN：

1753-4259

年：

2015

卷：

期：

页码：

587-597

DOI：

10.1177/1753425914566205

基金类别：

This study was supported by the National Natural Science Foundation of China (grant no. 30972213, 31372319); and National Basic Research Program of China (grant no. 2012CB126305).

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Acetaminophen (AAP) and N-acetylcysteine (NAC) have been found to have anti-inflammatory effects via the TLR-NF-Î°B pathway in LPS-challenged piglets. However, the action mechanisms employed by AAP and NAC have yet to be completely understood. This study investigated the anti-inflammatory effects and mechanisms of AAP and NAC on LPS-induced inflammatory responses via the NLRP3 inflammasome pathway in piglet mononuclear phagocytes. The results show that mRNA expression levels of IL-1β, IL-18 and NLRP3, as well as the protein level of cleaved ...

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The anti-inflammatory effects of acetaminophen and N-acetylcysteine through suppression of the NLRP3 inflammasome pathway in LPS-challenged piglet mononuclear phagocytes

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