期刊论文

Qiu, Yinsheng

英文

INNATE IMMUNITY

1753-4259

2016

22

3

196-204

10.1177/1753425916631032

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the National Natural Science Foundation of China (grant no. 30972213, 31572572).

本校为第一且通讯机构

In this study, the anti-inflammatory effects and mechanisms of baicalin on LPS-induced NLRP3 inflammatory pathway were investigated in piglet mononuclear phagocytes (control, LPS stimulation, LPS stimulation + 12.5 μg/ml baicalin, LPS stimulation + 25 μg/ml baicalin, LPS stimulation + 50 μg/ml baicalin and LPS stimulation + 100 μg/ml baicalin). The levels of reactive oxygen species (ROS), the secretion levels of IL-1β, IL-18 and TNF-α, mRNA expression levels of IL-1β, IL-18, TNF-α and NLRP3, as well as the protein levels of cleaved casp...