MRP14 enhances the ability of macrophage to recruit T cells and promotes obesity-induced insulin resistance

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xia, Chang;Razavi, Michael;Rao, Xiaoquan;Braunstein, Zachary;Mao, Hong;...

通讯作者：

Zhong, Jixin;Zhao, Shi

作者机构：

[Xia, Chang] Wuhan Polytech Univ, Coll Hlth Sci & Nursing, Wuhan 430023, Hubei, Peoples R China.

[Xia, Chang; Zhong, Jixin; Simon, Daniel, I; Rajagopalan, Sanjay; Wang, Yunmei; Razavi, Michael] Case Western Reserve Univ, Cardiovasc Res Inst, Cleveland, OH 44106 USA.

[Rao, Xiaoquan] Oregon Hlth & Sci Univ, Oregon Inst Occupat Hlth Sci, Portland, OR 97239 USA.

[Braunstein, Zachary; Zhao, Shi] Ohio State Univ, Dept Internal Med, Columbus, OH 43210 USA.

[Mao, Hong] Huazhong Univ Sci & Technol, Wuhan Cent Hosp, Tongji Med Coll, Dept Endocrinol, Wuhan 430014, Hubei, Peoples R China.

通讯机构：

[Zhong, Jixin] C

[Zhao, Shi] O

Case Western Reserve Univ, Cardiovasc Res Inst, Cleveland, OH 44106 USA.

Ohio State Univ, Dept Internal Med, Columbus, OH 43210 USA.

语种：

英文

期刊：

International Journal of Obesity

ISSN：

0307-0565

年：

2019

卷：

期：

页码：

2434-2447

DOI：

10.1038/s41366-019-0366-4

基金类别：

National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [K01DK105108, K99ES026241]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81670431, 31870906, 81370942, Y2110580, 81101247]; National Science and Technology Major Project [2016YFC1305803]; American Heart AssociationAmerican Heart Association [17GRNT33670485]; American Association of Immunologists [CIIF-8745]; Hubei Regenerative Medicine Research Center

机构署名：

本校为第一机构

院系归属：

医学与健康学院

摘要：

OBJECTIVE: Myeloid-related protein-14 (MRP14) and its binding partner MRP8 play an essential role in innate immune function and have been implicated in a variety of inflammatory diseases. However, the role of MRP14 in obesity-induced inflammation and insulin resistance is not well defined. This study investigated the role of MRP14 in macrophage-mediated adipose tissue inflammation and obesity-induced insulin resistance. SUBJECTS AND RESULTS: Wild-type (WT) and Mrp14(-/-) mice were fed with a high-fat diet or normal chow for 12 weeks. Tissue-resident macrophages in both adipose tissue and liver...

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MRP14 enhances the ability of macrophage to recruit T cells and promotes obesity-induced insulin resistance

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