RNA-based nanomedicines and their clinical applications

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Su, Lin-Jia;Ji, Zi-Han;Xu, Mo-Xi;Zhu, Jia-Qing;Chen, Yi-Hai;...

通讯作者：

Wang, Yi;Lin, YX;Wang, Y

作者机构：

[Wang, Yi; Ji, Zi-Han; Wang, Y; Qiao, Jun-Fei; Lin, YX; Xu, Mo-Xi; Lin, Yao-Xin; Su, Lin-Jia; Chen, Yi-Hai; Zhu, Jia-Qing] Natl Ctr Nanosci & Technol NCNST, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.

[Ji, Zi-Han; Lin, YX; Xu, Mo-Xi; Lin, Yao-Xin] Univ Chinese Acad Sci UCAS, Beijing 100149, Peoples R China.

[Chen, Yi-Hai] Harbin Med Univ, Dept Breast Surg, Canc Hosp, Harbin 150081, Peoples R China.

[Qiao, Jun-Fei] Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan 430023, Peoples R China.

[Wang, Yi; Wang, Y] Ecole Polytech Fed Lausanne EPFL, Inst Bioengn, CH-1015 Lausanne, Switzerland.

通讯机构：

[Wang, Y; Lin, YX ] N

[Wang, Y ] E

Natl Ctr Nanosci & Technol NCNST, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.

Univ Chinese Acad Sci UCAS, Beijing 100149, Peoples R China.

Ecole Polytech Fed Lausanne EPFL, Inst Bioengn, CH-1015 Lausanne, Switzerland.

语种：

英文

关键词：

Diseases;Medical nanotechnology;Oligonucleotides;Antisense oligonucleotides;Clinical application;Clinical trial;Conjugate-based delivery system;Delivery systems;Messenger RNA;Nanoparticle-based delivery system;RNA molecules;RNA-based nanomedicine;RNA

期刊：

纳米研究(英文)

ISSN：

1998-0124

年：

2023

卷：

期：

页码：

13182-13204

DOI：

10.1007/s12274-023-6238-5

基金类别：

This work was supported by the National Natural Science Foundation of China (No. 32371458), the Key Research and Development Programs of the Ministry of Science and Technology (No. 2022YFA1205700), and the Basic Research Cooperation Special Foundation of Beijing-Tianjin-Hebei (Nos. H2022205047, 22JCZXJC00060, and E3B33911DF). Y.-X. L. thanks the start-up funding from the National Center for Nanoscience and Technology and Chinese Academy of Sciences.

机构署名：

本校为其他机构

院系归属：

化学与环境工程学院

摘要：

RNA-based nanomedicines encompass a range of therapeutic approaches that utilize RNA molecules or molecules that target RNAs for the treatment or prevention of diseases. These include antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), endogenous microRNAs (miRNAs), messenger RNAs (mRNAs), clustered regularly interspersed short palindromic repeats-associated protein 9 (CRISPR/Cas9), single guide RNAs (sgRNAs), as well as RNA aptamers. These therapeutic agents exert their effects through various mechanisms such as gene inhibition...

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