期刊论文

Zhang, JT;Wang, HB

英文

Colloids and Surfaces B: Biointerfaces

0927-7765

2025

250

114554

10.1016/j.colsurfb.2025.114554

CRediT authorship contribution statement Xu Chengzhi: Supervision, Resources. Liao Lixia: Software, Investigation. Kou Huizhi: Writing – review & editing, Writing – original draft, Data curation. Han Qingqiu: Investigation, Data curation. Zhang Juntao: Project administration, acquisition. Hou Yuanjing: Visualization, Data curation. Wang Haibo: Project administration, acquisition.

本校为第一且通讯机构

Collagen is one of the most important natural biopolymers, it plays its role as a load-bearing structure in tissues only after polymerizing into fibrils. DDR2 is a collagen-binding receptor tyrosine kinases, playing a role in the regulation of collagen-cell interactions. Here, we studied the recognition of collagen fibrils by DDR2 and the effect of fibrillogenesis on cell biological activity. Our results showed that for monomeric collagen, the binding affinity of DDR2 to mammalian porcine skin collagen is higher than that to fish collagen. When the assembly of collagen monomers into the collag...