Asparagine improves intestinal integrity, inhibits TLR4 and NOD signaling, and differently regulates p38 and ERK1/2 signaling in weanling piglets after LPS challenge:

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Shaokui;Liu, Yulan*;Wang, Xiuying;Wang, Haibo;Li, Shuang;...

通讯作者：

Liu, Yulan

作者机构：

[Zhang, Jing; Hu, Chien-An Andy; Liu, Yulan; Chen, Shaokui; Li, Shuang; Shi, Haifeng; Wang, Haibo; Pi, Dingan; Wang, Xiuying; Zhu, Huiling] Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan, Peoples R China.

[Hu, Chien-An Andy] Univ New Mexico, Sch Med, Dept Biochem & Mol Biol, Albuquerque, NM 87131 USA.

[Odle, Jack; Lin, Xi] North Carolina State Univ, Dept Anim Sci, Lab Dev Nutr, Raleigh, NC USA.

[Liu, Yulan] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.

通讯机构：

[Liu, Yulan] W

Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.

语种：

英文

关键词：

Asparagine;weanling piglets;intestine;lipopolysaccharide;inflammatory response

期刊：

INNATE IMMUNITY

ISSN：

1753-4259

年：

2016

卷：

期：

页码：

577-587

DOI：

10.1177/1753425916664124

基金类别：

The authors express their gratitude to the National Natural Science Foundation of China (31422053 and 31372318) and the Hubei Provincial Department of Education (T201508) for the financial support.

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Asparagine (Asn), an activator of ornithine decarboxylase (ODC), stimulates cell proliferation in intestinal epithelial cells. We hypothesized that Asn can mitigate LPS-induced injury of intestinal structure and barrier function by regulating inflammatory signaling pathways. We executed the following experiment using weanling pigs for each of the groups: (1) non-challenged control; (2) LPS-challenged control; (3) LPS + 0.5% Asn; (4) LPS + 1.0% Asn. After 21-d feeding, pigs received an i.p. injection of either saline or LPS. Four h after injecti...

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Asparagine improves intestinal integrity, inhibits TLR4 and NOD signaling, and differently regulates p38 and ERK1/2 signaling in weanling piglets after LPS challenge:

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