期刊论文

Guan, JT;Liu, L

英文

Journal of Drug Delivery Science and Technology

1773-2247

2025

113

107404

10.1016/j.jddst.2025.107404

CRediT authorship contribution statement Yunjun Mei: Visualization, Conceptualization. Dong Zeng: Visualization, Data curation. Yi Wang: Visualization, acquisition. Jintao Guan: Visualization, Methodology, Data curation. Liang Liu: Writing – review & editing, Visualization, acquisition, Formal analysis, Data curation. Sheng-Li Wu: Writing – review & editing, Resources, Methodology, acquisition, Conceptualization. Yifan Zhang: Software, Methodology, Investigation, Formal analysis, Data curation. Lichen Wang: Acknowledgments The research is supported by the National Natural Science Foundation of China (Grant No. 21602166), the Research of Wuhan Institute of Technology (000017/20QD04), the Innovation Project of Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education (LCX202306), and the Research of Wuhan Polytechnic University (118/53210052143).

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A critical challenge in advancing gene therapy lies in developing safe and efficient gene delivery vectors. While polyethyleneimine (PEI) demonstrates superior DNA condensation capacity as a non-viral vector, its clinical application is hindered by inherent cytotoxicity. To address these challenges, this study presents a novel gene delivery system utilizing natural polyphenol resveratrol (Res) as a cross-linker through its hydroxyl groups capable of interacting with the amino groups in PEI by chemical modification. Three resveratrol-modified PEI (Res-P600, Res-P1800 and Res-P10k) polymers were...