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Glutamate alleviates intestinal injury, maintains mTOR and suppresses TLR4 and NOD signaling pathways in weanling pigs challenged with lipopolysaccharide

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成果类型:
期刊论文
作者:
Qin, Qin;Xu, Xiao;Wang, Xiuying;Wu, Huanting;Zhu, Huiling;...
通讯作者:
Liu, Yulan
作者机构:
[Wu, Huanting; Qin, Qin; Xu, Xiao; Liu, Yulan; Hou, Yongqing; Wang, Xiuying; Zhu, Huiling] Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.
[Dai, Bing; Liu, Xiuting] Zhe Jiang Goshine Test Technol Co Ltd, Hangzhou 310030, Zhejiang, Peoples R China.
通讯机构:
[Liu, Yulan] W
Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.
语种:
英文
关键词:
Nodal Signaling Pathway;IL-1 Receptor-associated Kinase (IRAK1);Myeloid Differentiation Factor (MyD88);Tollip;TNF Receptor Associated Factor 6 (TRAF6)
期刊:
Scientific Reports
ISSN:
2045-2322
年:
2018
卷:
8
期:
1
页码:
15124
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31772615]; Project of the Hubei Provincial Department of Education [T201508]; State's Key Project of Research and Development Plan [2016YFD0501210]; Project of Hangzhou Qianjiang Distinguished Expert [3122]
机构署名:
本校为第一且通讯机构
院系归属:
动物科学与营养工程学院
摘要:
AbstractThis experiment aimed to explore whether glutamate (Glu) had beneficial effects on intestinal injury caused by Escherichia coli LPS challenge via regulating mTOR, TLRs, as well as NODs signaling pathways. Twenty-four piglets were allotted to 4 treatments including: (1) control group; (2) LPS group; (3) LPS + 1.0% Glu group; (4) LPS + 2.0% Glu group. Supplementation with Glu increased jejunal villus height/crypt depth ratio, ileal activities of lactase, maltase and sucrase, and RNA/DNA ratio and protein abundance of claudin-1 in jeju...

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