Effects of rosmarinic acid on immune response and intestinal microbiota in ovalbumin-induced intestinal allergy mice

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成果类型：

期刊论文

作者：

Yang, Qing;Jia, Binmei;Shang, Jieli;Wang, Xuanpei;Xu, Lin;...

通讯作者：

Zeng, HL;Gong, ZY

作者机构：

[Wang, Xuanpei; Gong, Zhiyong; Xu, Lin; Liu, Xin; Shang, Jieli; Yang, Qing; Fang, Min; Jia, Binmei] Wuhan Polytech Univ, Key Lab Deep Proc Major Grain & Oil, Minist Educ, Wuhan, Peoples R China.

[Wang, Xuanpei; Gong, Zhiyong; Xu, Lin; Liu, Xin; Shang, Jieli; Yang, Qing; Fang, Min; Jia, Binmei] Key Res Inst Humanities & Social Hubei Prov, Food Safety Res Ctr, Wuhan 430023, Peoples R China.

[Zeng, Fengbo] BioCSi Tech Lab Co Ltd, Wuhan, Peoples R China.

[Zeng, Hao-Long] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Lab Med, Wuhan, Peoples R China.

[Zeng, Hao-Long; Zeng, HL] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Lab Med, Wuhan 430030, Peoples R China.

通讯机构：

[Gong, ZY ] W

[Zeng, HL ] H

Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Lab Med, Wuhan 430030, Peoples R China.

Wuhan Polytech Univ, Key Lab Deep Proc Major Grain & Oil, Minist Educ, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

rosmarinic acid;anti-food allergy;cytokines;gut microbiota

期刊：

Journal of the Science of Food and Agriculture

ISSN：

0022-5142

年：

2024

卷：

104

期：

页码：

3002-3012

DOI：

10.1002/jsfa.13192

基金类别：

the National Natural Science Foundation of China (NSFC) Youth Found [31800676, 32001772]; National Natural Science Foundation of China (NSFC) Youth Found; Open Research Fund Program of Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education, China

机构署名：

本校为第一且通讯机构

摘要：

BACKGROUND: Rosmarinic acid (RA) is an active polyphenol that is widely found in various edible herbs. This study explored the potential anti-allergic activities and the underlying mechanisms of RA in ovalbumin (OVA)-induced intestinal allergic mice. RESULTS: Forty female BALB/c mice were randomly divided into five groups: control group, model group (OVA sensitized/challenged), RA-Low group (OVA sensitized/challenged, 30 mg kg(-1) RA intervention), RA-Middle group (OVA sensitized/challenged, 90 mg kg(-1) RA intervention) and RA-High group (...

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Effects of rosmarinic acid on immune response and intestinal microbiota in ovalbumin-induced intestinal allergy mice

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