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A facile and efficient approach for the synthesis of 3-arylthiazol-2(3H)-one

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成果类型:
期刊论文
作者:
Zhu, Yue;Wang, Qilin;Luo, Haofan;Wang, Zijuan;Zhang, Guolin*;...
通讯作者:
Zhang, Guolin;Yu, Yongping
作者机构:
[Zhang, Guolin; Luo, Haofan; Yu, Yongping; Wang, Zijuan; Zhu, Yue; Zhang, GL] Zhejiang Univ, Coll Pharmaceut Sci, Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou 310058, Zhejiang, Peoples R China.
[Wang, Qilin] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan, Hubei, Peoples R China.
通讯机构:
[Zhang, GL; Yu, YP] Z
Zhejiang Univ, Coll Pharmaceut Sci, Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou 310058, Zhejiang, Peoples R China.
语种:
英文
关键词:
Acyl azide;3-arylthiazol-2(3H)-one;1,4-dithiane-2,5-diol;facile synthesis;nucleophilic addition
期刊:
Synthetic Communications
ISSN:
0039-7911
年:
2019
卷:
49
期:
16
页码:
2066-2072
基金类别:
Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LY16H300001, 81673291, 81473074]; Osteoporosis & Breast Cancer Research Center, U.S.A.
机构署名:
本校为其他机构
院系归属:
生命科学与技术学院
摘要:
A facile and efficient method for synthesis of 3-arylthiazol-2(3H)-one through the reaction of acyl azide and 1,4-dithiane-2,5-diol was reported. This reaction proceeded at 80 degrees C at first and then in acidic condition at room temperature, to afford products in good yields for a wide range of substrates and a possible mechan...

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