Determination of 2,4-Dichlorophenoxyacetic acid (2,4-D) in rat serum for pharmacokinetic studies with a simple HPLC method

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成果类型：

期刊论文

作者：

Chen, Xiao;Zhang, Hongling*;Wan, Yanjian;Chen, Xi;Li, Yuanyuan*

通讯作者：

Zhang, Hongling;Li, Yuanyuan

作者机构：

[Chen, Xiao] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan, Hubei, Peoples R China.

[Zhang, Hongling] Wuhan Polytech Univ, Coll Hlth Sci & Nursing, Wuhan, Hubei, Peoples R China.

[Wan, Yanjian] Wuhan Ctr Dis Control & Prevent, Wuhan, Hubei, Peoples R China.

[Chen, Xi; Li, Yuanyuan] Minist Educ, Key Lab Environm & Hlth, Wuhan, Hubei, Peoples R China.

[Chen, Xi; Li, Yuanyuan] Minist Environm Protect, Wuhan, Hubei, Peoples R China.

通讯机构：

[Zhang, Hongling] W

[Li, Yuanyuan] M

[Li, Yuanyuan] H

Wuhan Polytech Univ, Coll Hlth Sci & Nursing, Wuhan, Hubei, Peoples R China.

Minist Educ, Key Lab Environm & Hlth, Wuhan, Hubei, Peoples R China.

语种：

英文

关键词：

High performance liquid chromatography;Oral administration;Pharmacokinetics;Acetonitrile;Body weight;Herbicides;Pesticides;Quality control

期刊：

PLOS ONE

ISSN：

1932-6203

年：

2018

卷：

期：

页码：

e0191149

DOI：

10.1371/journal.pone.0191149

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81372959]

机构署名：

本校为第一且通讯机构

院系归属：

生命科学与技术学院

医学与健康学院

摘要：

2,4-Dichlorophenoxyacetic acid (2,4-D) is a chlorophenoxy herbicide used worldwide. We describe a high-performance liquid chromatography (HPLC) method with UV detection for the determination of 2,4-D in female and male rat serum. This allows to observe the change of serum 2,4-D concentration in rats with time and its pharmacokinetics characteristics with a simple, rapid, optimized and validated method. The serum samples are pretreated and introduced into the HPLC system. The analytes are separated in a XDB-C18 column with a mobile phase of acetonitrile (solvent A) and 0.02 M ammonium acetate (...

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Determination of 2,4-Dichlorophenoxyacetic acid (2,4-D) in rat serum for pharmacokinetic studies with a simple HPLC method

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