期刊论文

Rao, J

英文

Food Bioscience

2212-4292

2025

68

106439

10.1016/j.fbio.2025.106439

CRediT authorship contribution statement Yahong Cheng: Writing – original draft, acquisition, Conceptualization. Yi Ding: Visualization, Methodology, Data curation. Ziyan Tang: Methodology, Data curation. Xiaoyi Lei: Methodology, Data curation. Yufang Ma: Methodology, Data curation. Mengxin Xia: Methodology, Data curation. Jiaying Li: Methodology, Data curation. Gaoge Hu: Software, Investigation. Jiahui Zhang: Resources, Formal analysis. Jing Rao: Writing – review & editing, Project administration. This study was supported by the National Natural Science Foundation of China (NSFC; Grant No. 82301650), and the Scientific Research Project of Wuhan Polytechnic University (Grant No. 2023Y66), and the Scientific Research Project of Wuhan Polytechnic University (Grant No. 2023RZ037).

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This study investigated the antiepileptic effects of polydatin (PD) and its potential mechanisms. Racine scoring and EEG were used to assess seizure severity in a PTZ-induced mouse epilepsy model. The results demonstrated that PD significantly reduced the intensity of seizures. Behavioral tests revealed that PD improved learning, memory, and motor coordination. Histological analysis using HE and Nissl staining showed that PD alleviated hippocampal neuronal damage. TUNEL staining further confirmed that PD effectively prevented neuronal apoptosis...