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Sestrin2 emerges as a regulator of ROS-mediated oxidative stress and apoptosis in the cadmium-induced liver injury of rare minnow (Gobiocypris rarus)

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成果类型:
期刊论文
作者:
Su, Liangxia*;Li, Huanhuan;Xia, Xue;Xiong, Xiaoqin;Ding, Yifan;...
通讯作者:
Su, Liangxia;Liu, Jun
作者机构:
[Su, Liangxia] School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China. Electronic address: suliangxia027@126.com
[Xia, Xue; Ding, Yifan; Li, Huanhuan] School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China
[Xiong, Xiaoqin] Neijiang Normal University, Neijiang 641100, China
[Liu, Jun] School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China. Electronic address: 673164434@qq.com
[He, Yongfeng] The Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei 430072, China
通讯机构:
[Su, Liangxia; Liu, Jun] S
School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China. Electronic address:
语种:
英文
关键词:
Cadmium;Liver damage;Nrf2 pathway;ROS-mediated mechanisms;Sestrin2
期刊:
Ecotoxicology and Environmental Safety
ISSN:
0147-6513
年:
2025
卷:
305
页码:
119196
机构署名:
本校为第一且通讯机构
院系归属:
动物科学与营养工程学院
摘要:
Cadmium plays no know functional role in any life-form, but has severe effects. To elucidate the mechanism of cadmium-induced liver injury, 120 rare minnows were used to collect samples or culture liver cell. Animal assays results showed that exposed to 5 µg/L or 10 µg/L cadmium for 28 d caused histological changes with increased histopathological condition index ( I h ), significantly increased the cadmium content and increased levels of reactive oxygen species (ROS) of rare minnow liver. The changed Sestrin2 (Sesn2) and nuclear factor ery...

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