Sestrin2 emerges as a regulator of ROS-mediated oxidative stress and apoptosis in the cadmium-induced liver injury of rare minnow (Gobiocypris rarus)

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成果类型：

期刊论文

作者：

Su, Liangxia*;Li, Huanhuan;Xia, Xue;Xiong, Xiaoqin;Ding, Yifan;...

通讯作者：

Su, Liangxia;Liu, Jun

作者机构：

[Su, Liangxia] School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China. Electronic address: suliangxia027@126.com

[Xia, Xue; Ding, Yifan; Li, Huanhuan] School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China

[Xiong, Xiaoqin] Neijiang Normal University, Neijiang 641100, China

[Liu, Jun] School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China. Electronic address: 673164434@qq.com

[He, Yongfeng] The Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei 430072, China

通讯机构：

[Su, Liangxia; Liu, Jun] S

School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China. Electronic address:

语种：

英文

关键词：

Cadmium;Liver damage;Nrf2 pathway;ROS-mediated mechanisms;Sestrin2

期刊：

Ecotoxicology and Environmental Safety

ISSN：

0147-6513

年：

2025

卷：

305

页码：

119196

DOI：

10.1016/j.ecoenv.2025.119196

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Cadmium plays no know functional role in any life-form, but has severe effects. To elucidate the mechanism of cadmium-induced liver injury, 120 rare minnows were used to collect samples or culture liver cell. Animal assays results showed that exposed to 5 µg/L or 10 µg/L cadmium for 28 d caused histological changes with increased histopathological condition index ( I h ), significantly increased the cadmium content and increased levels of reactive oxygen species (ROS) of rare minnow liver. The changed Sestrin2 (Sesn2) and nuclear factor ery...

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Sestrin2 emerges as a regulator of ROS-mediated oxidative stress and apoptosis in the cadmium-induced liver injury of rare minnow (Gobiocypris rarus)

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