Targeting Forward and Reverse EphB4/EFNB2 Signaling by a Peptide with Dual Functions

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成果类型：

期刊论文

作者：

Xiong, Chiyi;Wen, Yunfei;Zhao, Jun;Yin, Dengke;Xu, Lingyun;...

通讯作者：

Li, Chun

作者机构：

[Xiong, Chiyi; Li, Chun; Yao, Cody; Yin, Dengke; Xu, Lingyun; Zhao, Jun] Univ Texas MD Anderson Canc Ctr, Dept Canc Syst Imaging, Houston, TX 77054 USA.

[Chelariu-Raicu, Anca; Sood, Anil K.; Wen, Yunfei] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77054 USA.

[Chelariu-Raicu, Anca; Sood, Anil K.; Wen, Yunfei] Univ Texas MD Anderson Canc Ctr, Dept Reprod Med, Houston, TX 77054 USA.

[Yin, Dengke] Anhui Univ Chinese Med, Sch Pharm, Hefei 230012, Peoples R China.

[Xu, Lingyun] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.

通讯机构：

[Li, Chun] D

Departments of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77054, United States.

Center for RNAi and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77054, United States.

语种：

英文

期刊：

Scientific Reports

ISSN：

2045-2322

年：

2020

卷：

期：

页码：

1-14

DOI：

10.1038/s41598-020-57477-x

基金类别：

John S. Dunn Foundation; Center for RNAi and Non-Coding RNA at The University of Texas MD Anderson Cancer Center; Marsha Rivkin Center; National Comprehensive Cancer Network; U.S. National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [P50 CA217685, UH3 TR000943, R35 CA209904, P30CA016672]; American Cancer Society Research Professor AwardAmerican Cancer Society

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本校为其他机构

院系归属：

生命科学与技术学院

摘要：

The tyrosine kinase receptor EphB4 is frequently overexpressed in ovarian and other solid tumors and is involved in interactions between tumor cells and the tumor microenvironment, contributing to metastasis. Trans-interaction between EphB4 and its membrane-bound ligand ephrin B2 (EFNB2) mediates bi-directional signaling: forward EFNB2-to-EphB4 signaling suppresses tumor cell proliferation, while reverse EphB4-to-EFNB2 signaling stimulates the invasive and angiogenic properties of endothelial cells. Currently, no small molecule-based, dual-function, EphB4-binding peptides are available. Here, ...

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Targeting Forward and Reverse EphB4/EFNB2 Signaling by a Peptide with Dual Functions

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