National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81370246]; Fundamental Research Funds for the Wuhan Polytechnic University [2016J07]; Hubei science and technology plan project [2017CFB479]; Project of scientific research project of Hubei Provincial Department of Education [B2017079]
机构署名:
本校为第一且通讯机构
院系归属:
生命科学与技术学院
摘要:
Objective: To explore the toxicity of multi-walled carbon nanotubes (MWCNTs) on the liver lipid metabolism of offspring mice and the possible mechanisms involved. Method: Virgin female (16–18 g) and male (18–20 g) C57BL/6 mice were randomly divided into two groups: Control group and Test group. After anesthesia with chloral hydrate, the mice were administered 50 μL saline or dust solution by intratracheal instillation (Control group: 50 μL saline; Test group: 15 mg kg−1 MWCNTs). Mice were injected with these doses once a week for 13 weeks....